Department of Chemical and Biological Engineering and §Princeton Institute for the Science and Technology of Materials, Princeton University , Princeton, New Jersey 08544, United States.
ACS Appl Mater Interfaces. 2013 Sep 25;5(18):9167-71. doi: 10.1021/am402585y. Epub 2013 Sep 6.
We present the synthesis and multifunctional utilization of core-shell Fe3O4 polydopamine nanoparticles (Fe3O4@PDA NPs) to serve as the enabling platform for a range of applications including responsive drug delivery, recyclable catalyst support, and adsorbent. Magnetite Fe3O4 NPs formed in a one-pot process by the hydrothermal approach were coated with a polydopamine shell layer of ~20 nm in thickness. The as prepared Fe3O4@PDA NPs were used for the controlled drug release in a pH-sensitive manner via reversible bonding between catechol and boronic acid groups of PDA and the anticancer drug bortezomib (BTZ), respectively. The facile deposition of Au NPs atop Fe3O4@PDA NPs was achieved by utilizing PDA as both the reducing agent and the coupling agent. The nanocatalysts exhibited high catalytic performance for the reduction of o-nitrophenol. Furthermore, the recovery and reuse of the catalyst was demonstrated 10 times without any detectible loss in activity. Finally, the PDA layers were converted into carbon to obtain Fe3O4@C and used as an adsorbent for the removal of Rhodamine B from an aqueous solution. The synergistic combination of unique features of PDA and magnetic nanoparticles establishes these core-shell NPs as a versatile platform for multiple applications.
我们提出了核壳型 Fe3O4 聚多巴胺纳米粒子（Fe3O4@PDA NPs）的合成及其多功能利用，将其作为一系列应用的平台，包括响应性药物输送、可回收催化剂载体和吸附剂。通过水热法在一锅法中形成的磁铁矿 Fe3O4 NPs 被厚度约为 20nm 的聚多巴胺壳层包覆。所制备的 Fe3O4@PDA NPs 可通过 PDA 中儿茶酚和硼酸基团之间的可逆键合以及分别与抗癌药物硼替佐米（BTZ）进行 pH 敏感的控释药物释放。通过利用 PDA 作为还原剂和偶联剂，可在 Fe3O4@PDA NPs 上轻松沉积 Au NPs。纳米催化剂对邻硝基苯酚的还原表现出高催化性能。此外，证明了催化剂的回收和再使用 10 次，而没有任何活性损失。最后，将 PDA 层转化为碳，得到 Fe3O4@C，并将其用作从水溶液中去除 Rhodamine B 的吸附剂。PDA 和磁性纳米粒子的独特特性的协同组合使这些核壳型 NPs 成为多功能应用的通用平台。
