Gazibara Tatjana, Nurkovic Selmina, Kisic-Tepavcevic Darija, Kurtagic Ilma, Kovacevic Nikolina, Gazibara Teodora, Pekmezovic Tatjana
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26A, 11000 Belgrade, Serbia.
Geriatr Nurs. 2013 Nov-Dec;34(6):486-90. doi: 10.1016/j.gerinurse.2013.08.002. Epub 2013 Sep 5.
From November 2012 to January 2013, 480 seniors were recruited at the Pubic Health Center in Belgrade, Serbia. The patients' records were validated by four independent investigators. Data on over-the-counter (OTC) drug use were collected through a questionnaire. Polypharmacy, an intake of ≥5 prescribed medications, reported in 10.4% of seniors, was associated with cardiovascular (odds ratio [OR] = 3.07; 95% confidence interval [CI] = 1.12-8.39) and endocrine diseases (OR = 2.25; 95% CI = 1.05-4.84) as well as with the number of treated chronic conditions (OR = 2.45; 95% CI = 1.75-3.44). The most frequently used OTC drugs were analgesics (metamizole, diclofenac and acetaminophen) and vitamins (vitamin C and vitamin B complex). The number of treated chronic conditions was associated with use of OTC drugs (OR = 1.17; 95% CI = 1.01-1.36). Multiple chronic conditions correlated with multiple OTC drug use (ρ = 0.125, p = 0.019). Our analysis indicated that the prevalence of polypharmacy and OTC drug use in the elderly are comparable to those in industrialized countries.
2012年11月至2013年1月，在塞尔维亚贝尔格莱德的公共卫生中心招募了480名老年人。患者记录由四名独立调查员进行核实。通过问卷调查收集非处方药（OTC）使用数据。在10.4%的老年人中报告了多重用药情况（即摄入≥5种处方药），这与心血管疾病（优势比[OR]=3.07；95%置信区间[CI]=1.12 - 8.39）、内分泌疾病（OR=2.25；95% CI=1.05 - 4.84）以及所治疗慢性病的数量（OR=2.45；95% CI=1.75 - 3.44）相关。最常使用的非处方药是镇痛药（安乃近、双氯芬酸和对乙酰氨基酚）和维生素（维生素C和复合维生素B）。所治疗慢性病的数量与非处方药的使用相关（OR=1.17；95% CI=1.01 - 1.36）。多种慢性病与多种非处方药的使用相关（ρ=0.125，p=0.019）。我们的分析表明，老年人中多重用药和非处方药使用的患病率与工业化国家相当。
