The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Endocrinol Metab Clin North Am. 2013 Sep;42(3):489-501. doi: 10.1016/j.ecl.2013.05.009.
Type 2 diabetes, like dementia, disproportionately affects the elderly. Diabetes has consistently been associated with risk of dementia, mild cognitive impairment, and cognitive decline suggesting that cognitive compromise is a deleterious manifestation of diabetes. This review summarizes observational studies and clinical trials of diabetes medications and their respective associations and effects on cognitive outcomes. Despite biological plausibility, results from most human clinical trials have failed to show any efficacy in treating Alzheimer disease symptomatology and pathology. Clinical trials targeting vascular-related outcomes, diabetic patients, or cognitively normal elderly at risk for dementia, may provide greater cognitive benefits.
2 型糖尿病与痴呆症一样,不成比例地影响老年人。糖尿病一直与痴呆症、轻度认知障碍和认知能力下降的风险相关,这表明认知障碍是糖尿病的一种有害表现。本综述总结了观察性研究和临床试验中糖尿病药物及其对认知结果的各自关联和影响。尽管具有生物学上的合理性,但大多数人体临床试验的结果都未能显示出任何治疗阿尔茨海默病症状和病理的疗效。针对血管相关结局、糖尿病患者或认知正常的痴呆高危老年人的临床试验可能会带来更大的认知益处。