Barkai E, Golan H, Grossman Y, Gutnick M J
Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel.
Eur J Pharmacol. 1990 Jun 21;182(1):167-9. doi: 10.1016/0014-2999(90)90507-3.
We have previously demonstrated that in pentylenetetrazole (PTZ)-kindled rats, cysteamine causes prolonged depression of the kindled state. We now report that administration of cysteamine before or during the kindling process prevents attainment of the kindled state. This effect lasts long after cysteamine administration has ceased, suggesting that depletion or somatostatin may not be the only mechanism underlying cysteamine's effect on kindling. The results also support the likelihood that PTZ kindling primarily effects neocortical rather than limbic structures.
我们之前已经证明，在戊四氮（PTZ）点燃的大鼠中，半胱胺会导致点燃状态的长时间抑制。我们现在报告，在点燃过程之前或期间给予半胱胺可阻止达到点燃状态。这种效应在停止给予半胱胺后仍持续很长时间，这表明生长抑素的耗竭可能不是半胱胺对点燃作用的唯一潜在机制。这些结果也支持了戊四氮点燃主要影响新皮质而非边缘结构的可能性。
