Cottrell G A, Robertson H A
Eur J Pharmacol. 1987 Feb 10;134(2):225-8. doi: 10.1016/0014-2999(87)90169-5.
A single injection of cysteamine, 200 mg/kg i.p., administered 4 h before a kindling session induces long-term suppression of kindled seizures. Injection of cysteamine 2, 4 or 6 h after or 24 h before the kindling session is either less effective or ineffective. The present series of experiments shows that the injection-to-kindled seizure interval is critically important for the long-term inhibition. We propose that the anticonvulsant effect is caused by an interaction of the cysteamine and the kindled seizure.
在点燃发作前4小时腹腔注射200mg/kg半胱胺，可诱导对点燃性癫痫发作的长期抑制。在点燃发作后2、4或6小时或点燃发作前24小时注射半胱胺，效果较差或无效。本系列实验表明，注射至点燃性癫痫发作的间隔时间对长期抑制至关重要。我们认为，抗惊厥作用是由半胱胺与点燃性癫痫发作的相互作用引起的。
