Tatsumi T, Komatsu H, Adachi J
Drug Development Laboratories, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
Jikken Dobutsu. 1990 Jul;39(3):353-9. doi: 10.1538/expanim1978.39.3_353.
The purpose of this paper was to examine the effect of chair restraint on plasma enzyme values in the rhesus monkey. Six monkeys were restrained to the monkey chair for eight hours. Creatine phosphokinase (CK) value increased significantly three hours after the onset of restraint and LDH value did eight hours after the onset of restraint. The increase in CK, GOT and GPT values continued for 1 or 2 days after the release from restraint. On the other hand, these plasma enzyme values in non-restraint monkeys showed almost no changes. These results indicate that it is necessary to establish a proper method for the adjustment to chair restraint in the rhesus monkey.
本文的目的是研究椅子束缚对恒河猴血浆酶值的影响。六只猴子被束缚在猴椅上八小时。束缚开始三小时后,肌酸磷酸激酶(CK)值显著升高,束缚开始八小时后,乳酸脱氢酶(LDH)值显著升高。束缚解除后,CK、谷草转氨酶(GOT)和谷丙转氨酶(GPT)值的升高持续1或2天。另一方面,未受束缚的猴子的这些血浆酶值几乎没有变化。这些结果表明,有必要建立一种适用于恒河猴的椅子束缚调整方法。