Uemura Osamu, Nagai Takuhito, Ishikura Kenji, Ito Shuichi, Hataya Hiroshi, Gotoh Yoshimitsu, Fujita Naoya, Akioka Yuko, Kaneko Tetsuji, Honda Masataka
Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, Obu, Aichi, 474-8710, Japan,
Clin Exp Nephrol. 2014 Aug;18(4):626-33. doi: 10.1007/s10157-013-0856-y. Epub 2013 Sep 7.
Renal inulin clearance is the gold standard for evaluation of kidney function, but cannot be measured easily in children. Therefore, we utilize the serum creatinine (Cr)-based estimated GFR (eGFR) measuring serum Cr by the enzymatic method, and we have reported simple serum Cr-based eGFR in Japanese children aged between 2 and 11 years old. Furthermore, we should use serum Cr-based eGFR in Japanese adolescents as well as children with chronic kidney disease for evaluation of renal function.
The inulin clearance and serum Cr level determined by an enzymatic method were measured in 131 pediatric chronic kidney disease (CKD) patients between the ages of 2 and 18 years old with no underlying disease affecting renal function except CKD to determine the serum Cr-based eGFR in Japanese children and adolescents.
We offer the complex estimated GFR equation using polynomial formulae for reference serum creatinine levels with body length in Japanese children except infants, resulting in the following equation:[Formula: see text] Reference serum Cr levels (y) are shown by the following two equations of body length (x):[Formula: see text]
The new polynomial eGFR formula showing the relationship with body length and serum Cr level may be applicable for clinical screening of renal function in Japanese children and adolescents aged between 2 and 18 years.
菊粉清除率是评估肾功能的金标准，但在儿童中不易测量。因此，我们采用基于血清肌酐（Cr）的估算肾小球滤过率（eGFR），通过酶法测量血清Cr，并且我们已经报道了适用于2至11岁日本儿童的基于血清Cr的简单eGFR。此外，我们应该在日本青少年以及患有慢性肾脏病的儿童中使用基于血清Cr的eGFR来评估肾功能。
对131名年龄在2至18岁之间、除慢性肾脏病外无其他影响肾功能基础疾病的小儿慢性肾脏病（CKD）患者，测量菊粉清除率和通过酶法测定的血清Cr水平，以确定日本儿童和青少年基于血清Cr的eGFR。
我们提供了使用多项式公式的复杂估算肾小球滤过率方程，用于除婴儿外的日本儿童参考血清肌酐水平与身长的关系，得出以下方程：[公式：见原文]参考血清Cr水平（y）由以下两个身长（x）方程表示：[公式：见原文]
新的显示身长与血清Cr水平关系的多项式eGFR公式可能适用于2至18岁日本儿童和青少年肾功能的临床筛查。
