Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, Obu, Aichi, Japan.
Clin Exp Nephrol. 2009 Dec;13(6):585-8. doi: 10.1007/s10157-009-0211-5. Epub 2009 Jul 24.
It is necessary to set the standard serum creatinine (Cr) values for the medical care of pediatric chronic kidney disease patients. The estimated glomerular filtration rate (eGFR, ml/min/1.73 m(2)) = kappa x body length (cm)/serum Cr value (mg/dl) determined by the Jaffe method devised by Schwartz has been used clinically. However, enzymatic methods have recently been used to measure Cr instead of the Jaffe method, making it necessary to reevaluate the coefficient kappa of the above equation. Following transformation of the above formula, the normal serum Cr level should be proportional to body length: normal serum Cr value (mg/dl) = k x body length (m).
Serum Cr values were measured by an enzymatic method in children who did not present with kidney disease or infectious disease, and the relationship between the body length and serum Cr level was determined by linear regression analysis.
We found a regression equation capable of estimating the reference value of serum Cr from body length. In children aged 1-12 years, body length (m) x 0.30 yielded a value similar to the reference serum Cr level.
There have been no previous reports of the determination of reference serum Cr levels by enzymatic methods in Japanese children. Our formula will be applicable for screening of renal function in Japanese children.
有必要为儿科慢性肾病患者的医疗保健设定标准血清肌酐（Cr）值。由 Schwartz 制定的 Jaffe 法测定的估算肾小球滤过率（eGFR，ml/min/1.73 m(2)）= kappa x 身高（cm）/血清 Cr 值（mg/dl）已在临床上使用。然而，最近已经使用酶法来测量 Cr，取代了 Jaffe 法，因此有必要重新评估上述方程的系数 kappa。将上述公式转换后，正常血清 Cr 水平应该与身高成正比：正常血清 Cr 值（mg/dl）= k x 身高（m）。
在没有肾脏疾病或传染病的儿童中，通过酶法测量血清 Cr 值，并通过线性回归分析确定身高与血清 Cr 水平之间的关系。
我们发现了一个能够从身高估计血清 Cr 参考值的回归方程。在 1-12 岁的儿童中，身高（m）x 0.30 得到的值与参考血清 Cr 水平相似。
以前没有关于日本儿童用酶法确定参考血清 Cr 水平的报道。我们的公式将适用于日本儿童肾功能的筛查。
