Department of Orthopedic Surgery, The Second Affiliated Hospital School of Medicine, Xi'an Jiaotong University, #157 Xi-wu Road Xi'an, Shaanxi, 710004, China,
Inflammation. 2014 Feb;37(1):170-6. doi: 10.1007/s10753-013-9727-7.
It is common for rheumatoid arthritis patients to suffer from persistent joint pain for decades during their lifetime. Activin A, a member of the transforming growth factor β superfamily, which plays a role in the very early phase of inflammatory processes, can also induce pain behaviors. In view of the contribution of synovial inflammation to the progression of rheumatoid arthritis, here we present the hypothesis that activin A may be a potential therapeutic target, serving as a marker for joint pain in which inflammatory processes are involved and as a target for early intervention.
类风湿关节炎患者在其一生中会经历数十年的持续性关节疼痛，这很常见。激活素 A 是转化生长因子 β 超家族的一员，它在炎症过程的早期阶段发挥作用，也可以诱导疼痛行为。鉴于滑膜炎症对类风湿关节炎进展的贡献，我们在这里提出假设，即激活素 A 可能是一个潜在的治疗靶点，可作为涉及炎症过程的关节痛的标志物，以及早期干预的靶点。
