Dauncey M J, Kamada T
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, England.
Horm Metab Res. 1990 Jul;22(7):374-7. doi: 10.1055/s-2007-1004925.
The influence of 3,5,3'-triiodothyronine (T3) on resting metabolic rate (RMR) has been examined in the young pig. A dose of 10, 20 or 40 nmol T3/kg body weight was infused intravenously for periods of between one and 4 h and oxygen consumption and activity were measured over the following 20 h. There was no change in RMR during the period of T3 infusion. Results 12-20 h after infusion were influenced neither by the time at which the animal was fed nor by the length of infusion. Immediately after infusion there was a marked increase in plasma T3 concentration, followed by a rapid decline. Levels were much higher than those recorded previously after feeding. Only after 40 nmol T3/kg was there a significant 12% increase in RMR during the period 12-20 h after infusion (P less than 0.02). The significance of these results in relation to the source of the postprandial increase in plasma T3 and the action of thyroid hormones at the cellular level is discussed.
在幼猪中研究了3,5,3'-三碘甲状腺原氨酸（T3）对静息代谢率（RMR）的影响。以10、20或40 nmol T3/千克体重的剂量静脉输注1至4小时，然后在接下来的20小时内测量耗氧量和活动情况。在T3输注期间，RMR没有变化。输注后12至20小时的结果既不受动物进食时间的影响，也不受输注时间长短的影响。输注后立即血浆T3浓度显著升高，随后迅速下降。其水平远高于先前喂食后记录的水平。仅在40 nmol T3/千克体重时，输注后12至20小时期间RMR才有显著的12%升高（P<0.02）。讨论了这些结果与餐后血浆T3升高的来源以及甲状腺激素在细胞水平的作用的相关性。
