Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Adv Clin Chem. 2013;61:33-65. doi: 10.1016/b978-0-12-407680-8.00002-6.
Biochemical markers of myocardial injury play an important role in the diagnosis of cardiovascular diseases. Measurement of cardiac biomarkers is one of the most important diagnostic tests in acute myocardial infarction (AMI), heart failure, and other cardiovascular disorders. Recently, the European Society of Cardiology, the American College of Cardiology Foundation, the American Heart Association, and the World Heart Federation have published a consensus definition of AMI that includes a detailed guideline for the assessment of biochemical markers in suspected disease. The cardiac troponins (cTI and cTnT) were recommended as preferred markers of myocardial necrosis in this setting. Herein, we review cardiac troponin biochemistry, the performance characteristics of cTnT assays, and optimal utilization of troponin in patients with proven or possible cardiovascular disease. We also discuss the use of troponin tests, with emphasis on cTnT, in different clinical situations in which its levels may be elevated.
心肌损伤的生化标志物在心血管疾病的诊断中起着重要作用。心脏标志物的测量是急性心肌梗死（AMI）、心力衰竭和其他心血管疾病最重要的诊断测试之一。最近，欧洲心脏病学会、美国心脏病学会基金会、美国心脏协会和世界心脏联盟发布了 AMI 的共识定义，其中包括对疑似疾病生化标志物评估的详细指南。在这种情况下，心肌钙蛋白（cTI 和 cTnT）被推荐为心肌坏死的首选标志物。本文综述了心肌钙蛋白的生化特性、cTnT 检测方法的性能特点以及在确诊或可能患有心血管疾病的患者中最佳使用肌钙蛋白的情况。我们还讨论了在其水平可能升高的不同临床情况下使用肌钙蛋白检测，重点是 cTnT。
