Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801; email:
Annu Rev Genet. 2013;47:209-32. doi: 10.1146/annurev-genet-111212-133445. Epub 2013 Aug 30.
Bacteria live in many dynamic environments with alternating cycles of feast or famine that have resulted in the evolution of mechanisms to quickly alter their metabolic capabilities. Such alterations often involve complex regulatory networks that modulate expression of genes involved in nutrient uptake and metabolism. A great number of protein regulators of metabolism have been characterized in depth. However, our ever-increasing understanding of the roles played by RNA regulators has revealed far greater complexity to regulation of metabolism in bacteria. Here, we review the mechanisms and functions of selected bacterial RNA regulators and discuss their importance in modulating nutrient uptake as well as primary and secondary metabolic pathways.
细菌生活在许多动态环境中，这些环境经历着丰饶和贫瘠的交替循环，这导致了它们进化出了快速改变代谢能力的机制。这种改变通常涉及调节参与营养物质摄取和代谢的基因表达的复杂调控网络。大量代谢的蛋白质调控因子已经被深入研究。然而，我们对 RNA 调控因子所起作用的认识不断加深，揭示了细菌代谢调控的复杂性。在这里，我们回顾了一些细菌 RNA 调控因子的作用机制和功能，并讨论了它们在调节营养物质摄取以及初级和次级代谢途径方面的重要性。
