Nemec A, Murphy B G, Jordan R C, Kass P H, Verstraete F J M
Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Slovenia; Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA.
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, USA.
J Comp Pathol. 2014 Feb-Apr;150(2-3):155-61. doi: 10.1016/j.jcpa.2013.07.007. Epub 2013 Sep 7.
Papillary squamous cell carcinoma (PSCC) is a distinct histological subtype of oral squamous cell carcinoma (SCC), described in both dogs and man. In dogs, PSCC has long been considered a malignant oral tumour of very young animals, but it has recently been reported to occur in adult dogs as well. The aim of this study was to describe the major clinicopathological characteristics of canine oral PSCC (COPSCC). Twelve dogs diagnosed with COPSCC were included in this retrospective study (1990-2012). The majority (75%) of the dogs were >6 years of age (median age 9 years). All tumours were derived from the gingiva of dentate jaws, with 66.7% affecting the rostral aspects of the jaws. The gross appearance of the lesions varied, with one having an intraosseous component only. The majority (91.7%) of the tumours were advanced lesions (T2 and T3), but no local or distant metastases were noted. Microscopically, two patterns were seen: (1) invasion of bone forming a cup-shaped indentation in the bone or a deeply cavitating cyst within the bone (cavitating pattern), (2) histologically malignant growth, but lack of apparent bone invasion (non-cavitating pattern). The microscopical appearance corresponded to imaging findings in a majority of cases, with cavitating forms presenting with a cyst-like pattern of bone loss or an expansile mass on imaging and non-cavitating forms showing an infiltrative pattern of bone destruction on imaging. These features suggest two distinct biological behaviours of COPSCC.
乳头状鳞状细胞癌（PSCC）是口腔鳞状细胞癌（SCC）一种独特的组织学亚型，在犬类和人类中均有描述。在犬类中，PSCC长期以来被认为是非常年轻动物的恶性口腔肿瘤，但最近有报道称其也可发生于成年犬。本研究的目的是描述犬口腔PSCC（COPSCC）的主要临床病理特征。本回顾性研究纳入了12只被诊断为COPSCC的犬（1990 - 2012年）。大多数（75%）犬的年龄大于6岁（中位年龄9岁）。所有肿瘤均起源于有牙颌的牙龈，其中66.7%累及颌骨的前部。病变的大体外观各不相同，其中1例仅具有骨内成分。大多数（91.7%）肿瘤为晚期病变（T2和T3），但未发现局部或远处转移。显微镜下可见两种模式：（1）肿瘤侵犯骨组织，在骨内形成杯状凹陷或骨内深部空洞性囊肿（空洞形成模式）；（2）组织学上为恶性生长，但无明显骨侵犯（非空洞形成模式）。在大多数病例中，显微镜下表现与影像学结果相符，空洞形成型在影像学上表现为囊肿样骨质破坏或膨胀性肿块，非空洞形成型在影像学上表现为浸润性骨质破坏模式。这些特征提示COPSCC具有两种不同的生物学行为。
