Wright Alexandra L, Peralta Santiago, Fiani Nadine
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Front Vet Sci. 2023 Oct 11;10:1281232. doi: 10.3389/fvets.2023.1281232. eCollection 2023.
To document a case of spontaneous regeneration of the mandibular body following subtotal mandibulectomy in a juvenile dog.
A 3-month-old male intact French bulldog was presented with papillary oral squamous cell carcinoma located at the dorsal aspect of the molar region of the left mandible. Initial biopsy of the mass was performed by the primary care veterinarian. Complete clinical staging revealed no signs of metastasis. Computed tomographic images of the head showed minimal contrast enhancement of the mass with no signs of periosteal or bone involvement. Subtotal mandibulectomy was performed. Histopathology indicated complete excision of the tumor. The patient returned 8-weeks later for follow up and cleft palate surgical repair, at which time bone was noted in the mandibulectomy area on palpation. Repeat computed tomography of the head revealed complete regeneration of the left mandibular body from the level of the ramus to the mandibular symphysis. No treatment for malocclusion was necessary due to the reformation of a functional mandible.
The present case demonstrates that spontaneous regeneration of the mandibular body is possible following subtotal mandibulectomy in immature dogs. Subtotal mandibulectomy is a radical procedure that can lead to long term complications including mandibular drift, malocclusion, and oral pain. This case report provides evidence that these sequelae may be mitigated or eliminated in young patients undergoing this procedure.
记录一只幼年犬下颌骨次全切除术后下颌体自发再生的病例。
一只3个月大的雄性未绝育法国斗牛犬，因左下颌磨牙区背侧出现乳头状口腔鳞状细胞癌前来就诊。初级保健兽医对肿块进行了初次活检。完整的临床分期显示无转移迹象。头部计算机断层扫描图像显示肿块的对比增强极小，无骨膜或骨质受累迹象。实施了下颌骨次全切除术。组织病理学检查表明肿瘤已完全切除。8周后患者返回进行随访及腭裂手术修复，此时触诊发现下颌骨切除区域有骨质。重复进行的头部计算机断层扫描显示，从下颌支到下颌联合处，左下颌体已完全再生。由于功能性下颌骨的重新形成，无需对咬合不正进行治疗。
本病例表明，幼年犬下颌骨次全切除术后下颌体自发再生是可能的。下颌骨次全切除术是一种根治性手术，可导致包括下颌骨移位、咬合不正和口腔疼痛在内的长期并发症。本病例报告提供了证据，表明接受该手术的年轻患者中，这些后遗症可能会减轻或消除。
