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[在给予添加抗氧化剂的致动脉粥样硬化日粮的家兔中纤维蛋白解聚和非酶纤维蛋白溶解过程]

[Process of fibrin depolymerization and non-enzymatic fibrinolysis in rabbits receiving atherogenic rations with addition of antioxidants].

作者信息

Kudriashov B A, Pastorova V E, Liapina L A, Kondashevskaia M V, Kobozeva L P

出版信息

Biull Eksp Biol Med. 1990 Oct;110(10):419-21.

PMID:2279098
Abstract

The rabbits were kept on atherogenic ration for 2 months. This diet contained 0.3 mg/kg of cholesterol. In blood plasma of animals the authors observed a sharply reduced non-enzymatic fibrinolysis and depolymerization activity of non-stabilized fibrin. The addition of antioxidants and alpha-tocopherol (10 + 10 mg/kg) for 1 month to the atherogenic ration protected from the disturbance of the system hemostasis and normalized the depolymerization of non-stabilized fibrin.

摘要

将兔子置于致动脉粥样化日粮喂养2个月。该日粮含有0.3毫克/千克胆固醇。作者观察到动物血浆中未稳定纤维蛋白的非酶纤维蛋白溶解和解聚活性急剧降低。在致动脉粥样化日粮中添加抗氧化剂和α-生育酚(10 + 10毫克/千克)1个月,可防止止血系统紊乱,并使未稳定纤维蛋白的解聚正常化。

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