Roll M, Zetterquist S
Department of Medicine, Karolinska Institute, Danderyd Hospital, Sweden.
J Intern Med. 1990 Sep;228(3):223-7. doi: 10.1111/j.1365-2796.1990.tb00222.x.
A hyperventilation provocation test (HVPT) was performed on a group (n = 63) of consecutive patients, below the age of 40 years, attending an emergency care unit complaining of chest pain without obvious organic cause. The results were compared with those for a control group (n = 32). There was no tendency to hyperventilate in the patient group, either after discontinuing hyperventilation or during the ensuing relaxation period. PETCO2 measurements during this time thus showed no significant differences between the patient group and the control group. During the HVPT, 44% of patients reported three or more listed symptoms familiar to them from earlier occasions and regarded as typical of hyperventilation, compared to 23% of the controls (P less than 0.05). In a previously reported study, 38% of the patients were found to have similar symptoms during standardized mental stress, despite lack of hypocapnia. It is concluded that, on the basis of PETCO2 measurements, there were no signs of abnormal hyperventilation in the patient group. Moreover, the HVPT did not appear to be specific for diagnosis of hyperventilation syndrome, since mental stress itself was able to reproduce symptoms without concomitant hypocapnia, and since the provocation test was 'positive' in many control subjects.
对一组（n = 63）年龄在40岁以下、因无明显器质性病因的胸痛而前往急诊护理单元就诊的连续患者进行了过度通气激发试验（HVPT）。将结果与对照组（n = 32）的结果进行比较。在患者组中，无论是停止过度通气后还是在随后的放松期，均无过度通气的倾向。因此，在此期间的呼气末二氧化碳分压（PETCO2）测量结果显示，患者组与对照组之间无显著差异。在HVPT期间，44%的患者报告出现了三种或更多他们之前经历过且被视为典型过度通气症状的所列症状，而对照组这一比例为23%（P < 0.05）。在先前报道的一项研究中，发现38%的患者在标准化心理应激期间出现了类似症状，尽管不存在低碳酸血症。得出的结论是，基于PETCO2测量结果，患者组没有异常过度通气的迹象。此外，HVPT似乎并非过度通气综合征诊断的特异性方法，因为心理应激本身就能在不伴有低碳酸血症的情况下引发症状，而且在许多对照受试者中激发试验呈“阳性”。
