Suppr超能文献

脊柱内固定对脊柱小立体定向放射外科剂量学的影响。

Effect of spine hardware on small spinal stereotactic radiosurgery dosimetry.

机构信息

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Phys Med Biol. 2013 Oct 7;58(19):6733-47. doi: 10.1088/0031-9155/58/19/6733. Epub 2013 Sep 9.

Abstract

Monte Carlo (MC) modeling of a 6 MV photon beam was used to study the dose perturbation from a titanium rod 5 mm in diameter in various small fields range from 2 × 2 to 5 × 5 cm(2). The results showed that the rod increased the dose to water by ∼6% at the water-rod interface because of electron backscattering and decreased the dose by ∼7% in the shadow of the rod because of photon attenuation. The Pinnacle(3) treatment planning system calculations matched the MC results at the depths more than 1 cm past the rod when the correct titanium density of 4.5 g cm(-3) was used, but significantly underestimated the backscattering dose at the water-rod interface. A CT-density table with a top density of 1.82 g cm(-3) (cortical bone) is a practical way to reduce the dosimetric error from the artifacts by preventing high density assignment to them, but can underestimates the attenuation by the titanium rod by 6%. However, when multi-beam with intensity modulation is used in actual patient spinal stereotactic radiosurgery treatment, the dosimetric effect of assigning 4.5 instead of 1.82 g cm(-3) to titanium implants is complicated. It ranged from minimal effect to 2% dose difference affecting 15% target volume in the study. When hardware is in the beam path, density override to the titanium hardware is recommended.

摘要

使用蒙特卡罗 (MC) 建模对 6 MV 光子束进行建模,以研究直径为 5 毫米的钛棒在各种小射野(范围从 2×2 至 5×5 cm²)中的剂量分布变化。结果表明,由于电子背散射,棒在水-棒界面处使水的剂量增加了约 6%,而由于光子衰减,在棒的阴影中使剂量减少了约 7%。当使用正确的钛密度 4.5 g/cm³时,Pinnacle(3) 治疗计划系统计算在棒后 1 cm 以上的深度与 MC 结果匹配,但在水-棒界面处显著低估了背散射剂量。使用顶部密度为 1.82 g/cm³(皮质骨)的 CT 密度表是一种实用的方法,可以通过防止将高密度分配给伪影来减少伪影引起的剂量误差,但会使钛棒的衰减低估 6%。然而,在实际的患者脊柱立体定向放射外科治疗中使用多波束强度调制时,将钛植入物的密度从 1.82 g/cm³更改为 4.5 g/cm³对剂量分布的影响是复杂的。在研究中,它的范围从最小的影响到影响 15%靶体积的 2%剂量差异。当硬件位于射束路径中时,建议对钛硬件进行密度覆盖。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验