Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Phys Med Biol. 2013 Oct 7;58(19):6733-47. doi: 10.1088/0031-9155/58/19/6733. Epub 2013 Sep 9.
Monte Carlo (MC) modeling of a 6 MV photon beam was used to study the dose perturbation from a titanium rod 5 mm in diameter in various small fields range from 2 × 2 to 5 × 5 cm(2). The results showed that the rod increased the dose to water by ∼6% at the water-rod interface because of electron backscattering and decreased the dose by ∼7% in the shadow of the rod because of photon attenuation. The Pinnacle(3) treatment planning system calculations matched the MC results at the depths more than 1 cm past the rod when the correct titanium density of 4.5 g cm(-3) was used, but significantly underestimated the backscattering dose at the water-rod interface. A CT-density table with a top density of 1.82 g cm(-3) (cortical bone) is a practical way to reduce the dosimetric error from the artifacts by preventing high density assignment to them, but can underestimates the attenuation by the titanium rod by 6%. However, when multi-beam with intensity modulation is used in actual patient spinal stereotactic radiosurgery treatment, the dosimetric effect of assigning 4.5 instead of 1.82 g cm(-3) to titanium implants is complicated. It ranged from minimal effect to 2% dose difference affecting 15% target volume in the study. When hardware is in the beam path, density override to the titanium hardware is recommended.
使用蒙特卡罗 (MC) 建模对 6 MV 光子束进行建模,以研究直径为 5 毫米的钛棒在各种小射野(范围从 2×2 至 5×5 cm²)中的剂量分布变化。结果表明,由于电子背散射,棒在水-棒界面处使水的剂量增加了约 6%,而由于光子衰减,在棒的阴影中使剂量减少了约 7%。当使用正确的钛密度 4.5 g/cm³时,Pinnacle(3) 治疗计划系统计算在棒后 1 cm 以上的深度与 MC 结果匹配,但在水-棒界面处显著低估了背散射剂量。使用顶部密度为 1.82 g/cm³(皮质骨)的 CT 密度表是一种实用的方法,可以通过防止将高密度分配给伪影来减少伪影引起的剂量误差,但会使钛棒的衰减低估 6%。然而,在实际的患者脊柱立体定向放射外科治疗中使用多波束强度调制时,将钛植入物的密度从 1.82 g/cm³更改为 4.5 g/cm³对剂量分布的影响是复杂的。在研究中,它的范围从最小的影响到影响 15%靶体积的 2%剂量差异。当硬件位于射束路径中时,建议对钛硬件进行密度覆盖。