Stern Debra J, Weisner Michael D, Courtney Sherry E
Department of Pediatrics, Division of Neonatology, Stony Brook Medicine, Stony Brook, New York.
Pediatr Pulmonol. 2014 Jul;49(7):659-64. doi: 10.1002/ppul.22880. Epub 2013 Sep 9.
(1) To evaluate the Graseby capsule (GC) as a respiratory detection device when compared to respiratory inductance plethysmography (RIP); (2) to evaluate the response to the Graseby signal of a commercially available bi-level nasal CPAP device (BNCPAP) designed for use with the GC; and (3) to assess the performance of the GC/BNCPAP device when fitted on preterm infants.
The study consisted of four parts: (1) The response characteristics of the GC/BNCPAP were assessed without connection to an infant; (2) the respiratory detection of both GC and RIP were compared in six preterm infants (mean 1,242 g, range 900-1,530 g); (3) the GC/BNCPAP was connected in six preterm infants (mean 1,568 g, range 1,040-1,835 g), isolating the BNCPAP and the infant interaction by substituting an artificial "nose" for the infant and assessing performance using inspiratory times (Ti) of 0.1 through 0.5 sec with pressure levels of both 10/6 and 8/5 cmH2 O; and (4) the GC/BNCPAP was employed as a respiratory support device in six preterm infants (mean 1,189 g, range 785-1,795 g) using clinically required pressures and evaluating performance using Ti of 0.3, 0.4 and 0.5 sec.
(1) Within 26 ms of stimulation of the GC, the BNCPAP initiated air flow; however, the time to reach peak pressure was much longer; (2) the GC, when placed in the subxiphoid position, tracked the RIP signal nearly identically and occurred sooner; (3) a Ti of at least 0.3 sec was required to reach the desired high pressure setting; and (4) synchrony of the GC/BNCPAP occurred in 72-74% of infant breaths.
The GC is a sensitive respiratory detection device; however, the GC/BNCPAP interface requires a minimum Ti of 0.3 sec and an adequate respiratory effort to achieve the desired pressure and to synchronously trigger the BNCPAP.
（1）与呼吸感应体积描记法（RIP）相比，评估格拉斯比胶囊（GC）作为一种呼吸检测设备；（2）评估一种专为与GC配合使用而设计的商用双水平鼻持续气道正压通气设备（BNCPAP）对格拉斯比信号的反应；（3）评估GC/BNCPAP设备安装在早产儿身上时的性能。
该研究包括四个部分：（1）在未与婴儿连接的情况下评估GC/BNCPAP的反应特性；（2）比较6名早产儿（平均体重1242克，范围900 - 1530克）中GC和RIP的呼吸检测情况；（3）在6名早产儿（平均体重1568克，范围1040 - 1835克）中连接GC/BNCPAP，用人工“鼻子”代替婴儿以隔离BNCPAP与婴儿的相互作用，并在吸气时间（Ti）为0.1至0.5秒、压力水平为10/6和8/5厘米水柱的情况下评估性能；（4）在6名早产儿（平均体重1189克，范围785 - 1795克）中使用临床所需压力将GC/BNCPAP用作呼吸支持设备，并在Ti为0.3、0.4和0.5秒的情况下评估性能。
（1）在刺激GC后26毫秒内，BNCPAP启动气流；然而，达到峰值压力的时间要长得多；（2）当GC置于剑突下位置时，其追踪RIP信号的情况几乎相同且更早出现；（3）需要至少0.3秒的Ti才能达到所需的高压设置；（4）GC/BNCPAP在72% - 74%的婴儿呼吸中实现同步。
GC是一种灵敏的呼吸检测设备；然而，GC/BNCPAP接口需要至少0.3秒的Ti和足够的呼吸努力才能达到所需压力并同步触发BNCPAP。
