Vincent Deirdre, Mietzsch Stefan, Braun Wolfgang, Trochimiuk Magdalena, Reinshagen Konrad, Boettcher Michael
Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Fritz Stephan GmbH, 56412 Gackenbach, Germany.
Children (Basel). 2023 Aug 21;10(8):1422. doi: 10.3390/children10081422.
(1) Background: As increases in intra-abdominal pressure (IAP) result in irreversible tissue damage, monitoring IAP in critically ill patients using the common urinary bladder catheter method is essential. However, this method can result in complications and is not suitable for very low birth weight neonates. The aim of this study was to establish a non-invasive and accurate method to detect IAP changes using an animal model. (2) Methods: IAP changes via intra-abdominal air application (up to 20 mmHg) were measured in 19 Wistar rats via an intra-abdominally placed intracranial pressure probe. Concurrently, abdominal surface tension was measured using a Graseby capsule (GC). (3) Results: A high correlation between abdominal wall distension and IAP (r = 0.9264, CI 0.9249-0.9279) was found for all subjects. (4) Conclusions: IAP changes in rats can be detected non-invasively using a GC. However, further studies are necessary to assess whether IAP changes can be measured using a GC in the neonatal population.
(1) 背景：由于腹腔内压力（IAP）升高会导致不可逆的组织损伤，因此使用普通膀胱导管法对危重症患者进行IAP监测至关重要。然而，这种方法可能会导致并发症，并且不适用于极低出生体重的新生儿。本研究的目的是使用动物模型建立一种无创且准确的方法来检测IAP变化。(2) 方法：通过腹腔内放置的颅内压探头，对19只Wistar大鼠施加腹腔内空气（高达20 mmHg）来测量IAP变化。同时，使用格雷西胶囊（GC）测量腹壁张力。(3) 结果：在所有受试者中，发现腹壁扩张与IAP之间存在高度相关性（r = 0.9264，CI 0.9249 - 0.9279）。(4) 结论：使用GC可以无创地检测大鼠的IAP变化。然而，有必要进一步研究评估在新生儿群体中是否可以使用GC测量IAP变化。
