Yokohama College of Pharmacy, Kanagawa, Japan .
Proc Jpn Acad Ser B Phys Biol Sci. 2007 Jun;83(5):127-35. doi: 10.2183/pjab.83.127.
The development of highly potent chiral discrimination methods that solve the problems of the diastereomer method, in which it is impossible to discriminate the diastereomers having chiral centers separated by more than four bonds, is described. On the basis of the results obtained, a new hypothesis, Induced Chiral Fields that the achiral reversed phase can provide chiral fields depending on the structures of the eluents, is proposed to explain the significant results of separation of the diastereomers derived from newly developed chiral and fluorescent labeling reagents and optical isomers by reversed-phase HPLC, which was hitherto impossible.
描述了发展高对映选择性手性拆分方法的情况，这些方法解决了非对映异构体方法的问题，在该方法中，不可能区分手性中心之间相隔超过四个键的非对映异构体。基于所获得的结果，提出了一个新的假设，即诱导手性场，即在反相条件下，根据洗脱剂的结构，可以提供手性场，以解释通过反相高效液相色谱法分离以前不可能实现的新开发的手性和荧光标记试剂和光学异构体衍生的非对映异构体的显著结果。
