Zhong Shan, Zhao Wei, Lu Chaojing, Li Bailing, Yuan Yang, Guo Danfeng, Chang Zhijie, Jiao Binhua, Yang Lixin
Institute of Biomedicine and School of Medicine, Tsinghua University, Beijing, 100084, People's Republic of China.
Tumour Biol. 2013 Aug;34(4):2403-7. doi: 10.1007/s13277-013-0790-3. Epub 2013 Apr 28.
Glutathione S-transferases (GSTs) play important roles in the detoxification of electrophilic carcinogens, and GSTM1 null genotype is associated with the dysfunction of GSTs. Previous studies investigating the association between GSTM1 null genotype and risk of esophageal carcinoma in Chinese provided inconsistent findings. To provide a more precise estimation on the association between GSTM1 null genotype and risk of esophageal carcinoma in Chinese population, a meta-analysis was performed. Eligible studies were searched in PubMed, Embase, and China National Knowledge Infrastructure databases. Odds ratio (OR) with the corresponding 95 % confidence interval (95 %CI) was used to assess the association. A total of 18 case-control studies involving 1,947 cases and 3,506 controls were finally included in the meta-analysis. Meta-analysis of those 18 studies showed that GSTM1 null genotype was associated with an increased risk of esophageal carcinoma in Chinese (random effect model OR = 1.49, 95 %CI = 1.11-2.00, P = 0.008). The findings from cumulative meta-analysis showed that the association was more obvious as the data increased by publication year. There was no risk of publication bias in the meta-analysis. Therefore, the findings from our meta-analysis provide a strong evidence for the association between GSTM1 null genotype and risk of esophageal carcinoma in Chinese population, and GSTM1 null genotype contributes to increased risk of esophageal carcinoma in Chinese.
谷胱甘肽S-转移酶（GSTs）在亲电子致癌物的解毒过程中发挥着重要作用，而GSTM1基因缺失型与GSTs功能障碍有关。以往关于中国人群中GSTM1基因缺失型与食管癌风险之间关联的研究结果并不一致。为了更精确地评估中国人群中GSTM1基因缺失型与食管癌风险之间的关联，我们进行了一项荟萃分析。在PubMed、Embase和中国知网数据库中检索符合条件的研究。采用比值比（OR）及其相应的95%置信区间（95%CI）来评估这种关联。最终，共有18项病例对照研究纳入了荟萃分析，涉及1947例病例和3506例对照。对这18项研究的荟萃分析表明，在中国人群中，GSTM1基因缺失型与食管癌风险增加有关（随机效应模型OR = 1.49，95%CI = 1.11 - 2.00，P = 0.008）。累积荟萃分析的结果表明，随着按发表年份增加的数据，这种关联更加明显。荟萃分析不存在发表偏倚风险。因此，我们荟萃分析的结果为中国人群中GSTM1基因缺失型与食管癌风险之间的关联提供了有力证据，并且GSTM1基因缺失型导致中国人群食管癌风险增加。
