Ratha-korn Vilaichone, Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani 12120, Thailand.
World J Gastroenterol. 2013 Sep 7;19(33):5508-12. doi: 10.3748/wjg.v19.i33.5508.
To survey the antibiotic resistance pattern of Helicobacter pylori (H. pylori) strains isolated from Bhutanese population.
We isolated 111 H. pylori strains from the gastric mucosa of H. pylori-infected patients in Bhutan in 2010. The Epsilometer test was used to determine the minimum inhibitory concentrations (MICs) of amoxicillin (AMX), clarithromycin (CLR), metronidazole (MNZ), levofloxacin (LVX), ciprofloxacin (CIP), and tetracycline (TET).
Nineteen of the isolated H. pylori strains were susceptible to all antibiotics tested. The isolated strains showed the highest rate of antibiotic resistance to MNZ (92/111, 82.9%). Among the 92 MNZ-resistant strains, 74 strains (80.4%) showed high-level resistance (MIC ≥ 256 μg/mL). Three strains were resistance to LVX (2.7%). These strains were also resistance to CIP. None of the strains showed resistance to CLR, AMX and TET.
CLR-based triple therapy is a more effective treatment approach over MNZ-based triple therapy for H. pylori infection in Bhutan.
调查从不丹人群中分离出的幽门螺杆菌（H. pylori）菌株的抗生素耐药模式。
我们于 2010 年从不丹感染 H. pylori 的患者胃黏膜中分离出 111 株 H. pylori 菌株。采用 Epsilometer 试验测定阿莫西林（AMX）、克拉霉素（CLR）、甲硝唑（MNZ）、左氧氟沙星（LVX）、环丙沙星（CIP）和四环素（TET）的最小抑菌浓度（MIC）。
19 株分离的 H. pylori 菌株对所有检测的抗生素均敏感。分离株对 MNZ 的耐药率最高（92/111，82.9%）。在 92 株 MNZ 耐药株中，74 株（80.4%）表现为高水平耐药（MIC≥256μg/ml）。3 株对 LVX（2.7%）耐药。这些菌株也对 CIP 耐药。没有菌株对 CLR、AMX 和 TET 表现出耐药性。
对于不丹的 H. pylori 感染，CLR 为基础的三联疗法比 MNZ 为基础的三联疗法更有效。
