Poli Giuseppe, Biasi Fiorella, Leonarduzzi Gabriella
Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Torino, Italy.
Redox Biol. 2013 Jan 31;1(1):125-30. doi: 10.1016/j.redox.2012.12.001.
Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism.
胆固醇代谢的27碳中间体或终产物（称为氧化甾醇）的病理性积累，可能导致主要慢性疾病的发生，尤其是其发展，在这些慢性疾病中，炎症、氧化损伤以及在一定程度上的细胞死亡是疾病进展的标志和主要机制。事实上，某些氧化甾醇在动脉粥样硬化、神经退行性疾病、炎症性肠病、年龄相关性黄斑变性以及其他以胆固醇摄取和/或代谢改变为特征的病理状况典型病变中可检测到的浓度下，发挥强烈的促氧化和促炎作用。
