蛋白酶体与氧化蛋白质的降解：第一部分 - 蛋白酶体的结构 - Suppr

Jung Tobias, Grune Tilman

Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.

Redox Biol. 2013 Jan 19;1(1):178-82. doi: 10.1016/j.redox.2013.01.004.

The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular metabolism. For this aim a complex system of regulators evolved, modifying the function of the 20S core proteasome. Here we summarize shortly the structure of the 20S proteasome as well as its associated regulator proteins.

负责细胞蛋白质维持的主要机制是泛素-蛋白酶体系统，其核心颗粒是20S蛋白酶体。该系统的主要任务是快速有效地降解细胞代谢中不再需要的蛋白质。为此，进化出了一个复杂的调节系统，以改变20S核心蛋白酶体的功能。在此，我们简要总结20S蛋白酶体的结构及其相关调节蛋白。