Figus Michele, Posarelli Chiara, Nasini Francesco, Perrini Paolo, Miccoli Mario, Baggiani Angelo, Ferreras Antonio, Nardi Marco
Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.
Department of Neurosurgery 2, University of Pisa, 56124 Pisa, Italy.
Biomed Res Int. 2015;2015:756261. doi: 10.1155/2015/756261. Epub 2015 Feb 22.
BACKGROUND/AIMS: To evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls.
Cross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants.
CMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P < 0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye.
A distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.
背景/目的：与健康对照相比，使用光谱域光学相干断层扫描（OCT）评估Chiari I型畸形（CMI）患者的视神经乳头。
横断面研究。对22例CMI患者和22例健康对照的视神经乳头进行OCT定量分析。健康对照在年龄和性别上与研究人群相匹配。计算双眼平均视网膜神经纤维层（RNFL）厚度；还记录每个象限以及四个象限中每个子区域的平均厚度值。
CMI患者双眼RNFL厚度均降低。右眼下方象限以及每个象限的这种降低在统计学上更显著（P < 0.05），而左眼鼻侧象限则不然。
视网膜神经纤维受损可能解释了CMI患者中观察到的RNFL厚度降低；在我们的系列研究中，当CMI与脊髓空洞症相关时，RNFL厚度的降低似乎较小。
