Flynn J, Rudert M J, Olson E, Baratz M, Hanley E
Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania.
Spine (Phila Pa 1976). 1990 Jun;15(6):567-70. doi: 10.1097/00007632-199006000-00025.
The transplantation of spinal allografts to correct defects that include disc, body, or segments of both is currently under experimental investigation. A method of graft preservation that will least compromise the biomechanical integrity of the bodies or discs is required. Using a five-mode biomechanical analysis, the authors compared the change in stiffness of ten preserved canine spines. The freeze-dried specimens lost a significantly greater amount of stiffness in compression, flexion, extension, and torsion than did the frozen specimens. Therefore, from a biomechanical viewpoint, deep-freezing is superior to freeze-drying for spinal allograft preservation.
目前正在对同种异体脊柱移植以纠正包括椎间盘、椎体或两者节段在内的缺损进行实验研究。需要一种对椎体或椎间盘的生物力学完整性损害最小的移植物保存方法。作者使用五模式生物力学分析比较了十个保存的犬类脊柱的刚度变化。冻干标本在压缩、屈曲、伸展和扭转时失去的刚度比冷冻标本显著更多。因此，从生物力学角度来看，深度冷冻在同种异体脊柱移植物保存方面优于冻干。
