Neuroscience Research Australia, Barker Street, PO Box 1165, Randwick, NSW, 2031, Australia,
Curr Neurol Neurosci Rep. 2013 Nov;13(11):396. doi: 10.1007/s11910-013-0396-6.
Logopenic progressive aphasia is the most recently described clinical variant of primary progressive aphasia (PPA), defined by impairment of lexical retrieval and sentence repetition. Unlike other PPA variants, the logopenic variant of PPA (lv-PPA) is commonly associated with Alzheimer's disease (AD), a fact that is relevant to the selection of patients for clinical trials and disease-modifying therapies. Despite the straightforward definition and coherent pathological association, the existence of lv-PPA has been challenged, as its distinction from AD or other PPA variants can be difficult. Despite these issues, lv-PPA patients display characteristic linguistic deficits, a pattern of brain atrophy, and possibly genetic susceptibility, which warrant considering this variant as a discrete AD endophenotype. More specific clinical and anatomical markers can strengthen the consistency of this syndrome.
失语法型进行性失语症是原发性进行性失语症（PPA）中最近描述的临床变异型，其特征为词汇检索和句子重复受损。与其他 PPA 变异型不同，失语法型 PPA（lv-PPA）通常与阿尔茨海默病（AD）相关，这一事实与患者选择进行临床试验和疾病修饰治疗相关。尽管存在明确的定义和连贯的病理学关联，但 lv-PPA 的存在一直受到质疑，因为其与 AD 或其他 PPA 变异型的区分可能很困难。尽管存在这些问题，但 lv-PPA 患者表现出特征性的语言缺陷、大脑萎缩模式，以及可能的遗传易感性，这使得将这种变异型视为一种离散的 AD 内表型是合理的。更具体的临床和解剖学标志物可以增强这种综合征的一致性。
