中东呼吸综合征冠状病毒辅助蛋白 4a 是一种 I 型干扰素拮抗剂。
Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.
机构信息
Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
出版信息
J Virol. 2013 Nov;87(22):12489-95. doi: 10.1128/JVI.01845-13. Epub 2013 Sep 11.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.
摘要
中东呼吸综合征冠状病毒（MERS-CoV）可引起严重的急性呼吸道感染，其流行病学目前尚不清楚。我们之前的研究表明，MERS-CoV 可拮抗人支气管细胞固有免疫反应的某些部分。在此，我们分析了辅助蛋白 3、4a、4b 和 5 抑制 I 型干扰素反应的能力。辅助蛋白 4a 被发现通过与双链 RNA 的直接相互作用，在黑色素瘤分化相关蛋白 5（MDA5）激活水平上阻断干扰素的诱导。
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