Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA.
Trends Cogn Sci. 2013 Oct;17(10):510-6. doi: 10.1016/j.tics.2013.08.007. Epub 2013 Sep 9.
Brain amyloid can be measured using positron emission tomography (PET). There are mixed reports regarding whether amyloid measures are correlated with measures of cognition (in particular memory), depending on the cohorts and cognitive domains assessed. In Alzheimer's disease (AD) patients and those at heightened risk for AD, cognitive performance may be related to the level and extent of classical AD pathology (amyloid plaques and neurofibrillary angles), but it is also influenced by neurodegeneration, neurocognitive reserve, and vascular health. We discuss what recent neuroimaging research has discovered about cognitive deficits in AD and offer suggestions for future research.
脑淀粉样蛋白可以通过正电子发射断层扫描（PET）进行测量。根据评估的队列和认知领域的不同，淀粉样蛋白测量值与认知（特别是记忆）测量值是否相关存在混合报告。在阿尔茨海默病（AD）患者和 AD 高危人群中，认知表现可能与经典 AD 病理（淀粉样斑块和神经纤维缠结）的水平和程度有关，但也受到神经退行性变、神经认知储备和血管健康的影响。我们讨论了最近神经影像学研究对 AD 认知缺陷的发现，并为未来的研究提供了建议。
