Child and Adolescent Studies, Utrecht University, 3508 TC Utrecht, The Netherlands.
J Subst Abuse Treat. 2014 Feb;46(2):120-7. doi: 10.1016/j.jsat.2013.08.008. Epub 2013 Sep 9.
The aim of this randomized, double-blind placebo-controlled clinical trial is to test the efficacy and safety of nicotine replacement therapy (NRT) in promoting end-of-treatment abstinence among adolescents and whether this relation is moderated by medication compliance. Participants (N=257, age: 16.7±1.13 years) attended an information meeting followed by a 6- or 9-week treatment. Self-reported smoking cessation, compliance, and side effects were measured by means of online questionnaires. Intent-to-treat analyses showed that independent of compliance, NRT is effective in promoting abstinence rates after 2 weeks (OR=2.02, 95% CI=1.11-3.69), but not end-of-treatment abstinence. However, end-of-treatment abstinence rates significantly increased in high-compliant (OR=1.09, 95% CI=1.01-1.17) and not in low-compliant participants. No serious adverse events were found. Future research is warranted to disentangle the process involving the decrease in abstinence rates and compliance rates from the third week after the quit date onwards.
本随机、双盲、安慰剂对照临床试验旨在测试尼古丁替代疗法（NRT）在促进青少年治疗结束时戒烟方面的疗效和安全性，以及这种关系是否受药物依从性的调节。参与者（N=257，年龄：16.7±1.13 岁）参加了一个信息会议，随后进行了 6 或 9 周的治疗。通过在线问卷测量自我报告的戒烟、依从性和副作用。意向治疗分析表明，无论依从性如何，NRT 在治疗 2 周后促进戒烟率的效果显著（OR=2.02，95%CI=1.11-3.69），但对治疗结束时的戒烟率没有影响。然而，在高依从性（OR=1.09，95%CI=1.01-1.17）而非低依从性参与者中，治疗结束时的戒烟率显著增加。未发现严重不良事件。需要进一步研究以厘清从戒烟日期后的第三周开始，戒烟率和依从率下降与什么有关。
