PET Center, Department of Pediatrics, Neurology, and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan.
J Nucl Med. 2013 Oct;54(10):1775-81. doi: 10.2967/jnumed.112.114397. Epub 2013 Aug 22.
Epilepsy is one of the most common yet diverse neurologic disorders, affecting almost 1%-2% of the population. Presently, radionuclide imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations, such as in noninvasive presurgical localization of epileptogenic brain regions in intractable-seizure patients being considered for epilepsy surgery. Radionuclide imaging can be particularly useful if MR imaging is either negative for lesions or shows several lesions of which only 1 or 2 are suspected to be epileptogenic and if electroencephalogram changes are equivocal or discordant with the structural imaging. Similarly, PET and SPECT can also be useful for evaluating the functional integrity of the rest of the brain and may provide useful information on the possible pathogenesis of the neurocognitive and behavioral abnormalities frequently observed in these patients.
癫痫是最常见但又多种多样的神经障碍之一，影响着近 1%-2%的人口。目前，正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）等放射性核素成像技术并未用于新发癫痫的初步诊断或评估。然而，在某些特定情况下，它可以发挥独特且重要的作用，例如在考虑进行癫痫手术的难治性癫痫患者中，对致痫性脑区进行非侵入性术前定位。如果磁共振成像（MRI）对病变呈阴性或显示出多个病变，而只有 1 个或 2 个病变被怀疑致痫，并且脑电图（EEG）改变不明确或与结构成像不一致，则放射性核素成像特别有用。同样，PET 和 SPECT 也可用于评估大脑其余部分的功能完整性，并可能为这些患者经常出现的神经认知和行为异常的可能发病机制提供有用信息。
