Chen Jerry S, Longaker Michael T, Gurtner Geoffrey C
Department of Surgery, Stanford University, Stanford, CA, USA.
Methods Mol Biol. 2013;1037:265-74. doi: 10.1007/978-1-62703-505-7_15.
In vivo wound healing experiments remain the most predictive models for studying human wound healing, allowing an accurate representation of the complete wound healing environment including various cell types, environmental cues, and paracrine interactions. Small animals are economical, easy to maintain, and allow researchers to take advantage of the numerous transgenic strains that have been developed to investigate the specific mechanisms involved in wound healing and regeneration. Here we describe three reproducible murine wound healing models that recapitulate the human wound healing process.
体内伤口愈合实验仍然是研究人类伤口愈合最具预测性的模型，能够准确呈现完整的伤口愈合环境，包括各种细胞类型、环境线索和旁分泌相互作用。小型动物经济实惠、易于饲养，并且使研究人员能够利用已开发的众多转基因品系来研究伤口愈合和再生所涉及的具体机制。在此，我们描述三种可重复的小鼠伤口愈合模型，它们概括了人类伤口愈合过程。
