*Department of Oncology, Xiangya Hospital, Central South University, Changsha †Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.
J Clin Gastroenterol. 2013 Oct;47(9):741-8. doi: 10.1097/MCG.0b013e31829e446b.
: To conduct a meta-analysis on the relationship between the usage of bisphosphonates and the risk of colorectal cancer.
We searched PUBMED and EMBASE for studies assessing colorectal cancer incidence or prevalence in bisphosphonate users versus nonusers that were published before August 2012. We used the STATA software to calculate the pooled odds ratios (OR) and 95% confidence interval (CI) for the risk of colorectal cancer associated with exposure to bisphosphonates using a random-effects model.
Eight studies met our inclusion criteria, which comprised 5 cohort studies and 3 case-control studies, with a total of 22,291 colorectal cancer cases. The usage of bisphosphonates was associated with a statistically significant decrease in colorectal cancer risk, with a pooled OR of 0.89 (95% CI, 0.80-0.99). A statistically significant decrease in the risk of colorectal cancer was observed in the long-term exposure groups (pooled OR, 0.73; 95% CI, 0.57-0.93).
These results indicate that the decrease in risk of colorectal cancer may be associated with the usage of bisphosphonates. More studies are needed to confirm the relationship.
对双膦酸盐的使用与结直肠癌风险之间的关系进行荟萃分析。
我们检索了 PUBMED 和 EMBASE，以查找 2012 年 8 月之前发表的评估双膦酸盐使用者与非使用者结直肠癌发病率或患病率的研究。我们使用 STATA 软件，采用随机效应模型，计算了与暴露于双膦酸盐相关的结直肠癌风险的合并比值比（OR）和 95％置信区间（CI）。
符合纳入标准的有 8 项研究，包括 5 项队列研究和 3 项病例对照研究，共有 22291 例结直肠癌病例。双膦酸盐的使用与结直肠癌风险的统计学显著降低相关，合并 OR 为 0.89（95％CI，0.80-0.99）。长期暴露组的结直肠癌风险也呈现统计学显著降低（合并 OR，0.73；95％CI，0.57-0.93）。
这些结果表明，结直肠癌风险的降低可能与双膦酸盐的使用有关。需要更多的研究来证实这种关系。
