口服双膦酸盐与结直肠癌风险：一项荟萃分析。

Oral bisphosphonates and the risk of colorectal cancer: a meta-analysis.

机构信息

*Department of Oncology, Xiangya Hospital, Central South University, Changsha †Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.

出版信息

J Clin Gastroenterol. 2013 Oct;47(9):741-8. doi: 10.1097/MCG.0b013e31829e446b.

DOI:10.1097/MCG.0b013e31829e446b

PMID:24030705

Abstract

AIM

: To conduct a meta-analysis on the relationship between the usage of bisphosphonates and the risk of colorectal cancer.

METHODS

We searched PUBMED and EMBASE for studies assessing colorectal cancer incidence or prevalence in bisphosphonate users versus nonusers that were published before August 2012. We used the STATA software to calculate the pooled odds ratios (OR) and 95% confidence interval (CI) for the risk of colorectal cancer associated with exposure to bisphosphonates using a random-effects model.

RESULTS

Eight studies met our inclusion criteria, which comprised 5 cohort studies and 3 case-control studies, with a total of 22,291 colorectal cancer cases. The usage of bisphosphonates was associated with a statistically significant decrease in colorectal cancer risk, with a pooled OR of 0.89 (95% CI, 0.80-0.99). A statistically significant decrease in the risk of colorectal cancer was observed in the long-term exposure groups (pooled OR, 0.73; 95% CI, 0.57-0.93).

CONCLUSIONS

These results indicate that the decrease in risk of colorectal cancer may be associated with the usage of bisphosphonates. More studies are needed to confirm the relationship.

摘要

目的

对双膦酸盐的使用与结直肠癌风险之间的关系进行荟萃分析。

方法

我们检索了 PUBMED 和 EMBASE，以查找 2012 年 8 月之前发表的评估双膦酸盐使用者与非使用者结直肠癌发病率或患病率的研究。我们使用 STATA 软件，采用随机效应模型，计算了与暴露于双膦酸盐相关的结直肠癌风险的合并比值比（OR）和 95％置信区间（CI）。

结果

符合纳入标准的有 8 项研究，包括 5 项队列研究和 3 项病例对照研究，共有 22291 例结直肠癌病例。双膦酸盐的使用与结直肠癌风险的统计学显著降低相关，合并 OR 为 0.89（95％CI，0.80-0.99）。长期暴露组的结直肠癌风险也呈现统计学显著降低（合并 OR，0.73；95％CI，0.57-0.93）。