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Braz J Microbiol. 2010 Apr;41(2):345-8. doi: 10.1590/S1517-838220100002000013. Epub 2010 Jun 1.
2
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引用本文的文献

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Overview of the Anticancer Potential of the "King of Spices" and Its Main Constituent Piperine.“香料之王”及其主要成分胡椒碱的抗癌潜力概述。
Toxins (Basel). 2020 Nov 26;12(12):747. doi: 10.3390/toxins12120747.
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Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1.胡椒碱对黄曲霉毒素B1中毒肉鸡的抗遗传毒性作用。
Toxins (Basel). 2016 Oct 31;8(11):316. doi: 10.3390/toxins8110316.

本文引用的文献

1
Cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study.胡椒碱对小鼠脾细胞的细胞保护和免疫调节特性：一项体外研究。
Eur J Pharmacol. 2007 Dec 8;576(1-3):160-70. doi: 10.1016/j.ejphar.2007.07.033. Epub 2007 Jul 25.
2
Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis.
Mol Cell Biochem. 2005 Jan;268(1-2):141-7. doi: 10.1007/s11010-005-3702-z.
3
Immunotoxicological effects of piperine in mice.
Toxicology. 2004 Mar 15;196(3):229-36. doi: 10.1016/j.tox.2003.10.006.
4
Inhibition of various functions in murine peritoneal macrophages by aflatoxin B1 exposure in vivo.体内黄曲霉毒素B1暴露对小鼠腹腔巨噬细胞多种功能的抑制作用。
Int J Immunopharmacol. 1999 Jan;21(1):47-58. doi: 10.1016/s0192-0561(98)00069-1.
5
Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1.胡椒碱可抑制黄曲霉毒素B1在经基因工程改造以表达大鼠细胞色素P4502B1的V79中国仓鼠细胞中诱导的细胞毒性和遗传毒性。
J Ethnopharmacol. 1997 Nov;58(3):165-73. doi: 10.1016/s0378-8741(97)00104-9.
6
Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line.
Biochem Biophys Res Commun. 1996 Jan 17;218(2):562-9. doi: 10.1006/bbrc.1996.0100.
7
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.胡椒碱提高药物生物利用度的生化基础：胡椒碱是药物代谢的强效抑制剂的证据。
J Pharmacol Exp Ther. 1985 Jan;232(1):258-62.

胡椒堿经口给药对控制大鼠黄曲霉毒素中毒的作用。

Oral administration of piperine for the control of aflatoxin intoxication in rats.

机构信息

Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro , Seropédica, RJ , Brasil.

出版信息

Braz J Microbiol. 2010 Apr;41(2):345-8. doi: 10.1590/S1517-838220100002000013. Epub 2010 Jun 1.

DOI:10.1590/S1517-838220100002000013
PMID:24031502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3768673/
Abstract

Aflatoxins are mycotoxins that have important toxic effects on human and animal health, even if consumed at low doses. The oral administration of piperine (1.12 mg/kg) during 23 days in rats seemingly interfered with the toxicity of aflatoxins, decreasing hepatic injuries and the leukocyte depletion in experimentally intoxicated animals.

摘要

黄曲霉毒素是一种真菌毒素，即使低剂量摄入，也会对人类和动物健康产生重要的毒性影响。在大鼠中连续 23 天口服胡椒碱（1.12mg/kg），似乎可以干扰黄曲霉毒素的毒性，减少实验性中毒动物的肝损伤和白细胞耗竭。