胡椒堿经口给药对控制大鼠黄曲霉毒素中毒的作用。
Oral administration of piperine for the control of aflatoxin intoxication in rats.
机构信息
Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro , Seropédica, RJ , Brasil.
出版信息
Braz J Microbiol. 2010 Apr;41(2):345-8. doi: 10.1590/S1517-838220100002000013. Epub 2010 Jun 1.
Abstract
Aflatoxins are mycotoxins that have important toxic effects on human and animal health, even if consumed at low doses. The oral administration of piperine (1.12 mg/kg) during 23 days in rats seemingly interfered with the toxicity of aflatoxins, decreasing hepatic injuries and the leukocyte depletion in experimentally intoxicated animals.
摘要
黄曲霉毒素是一种真菌毒素，即使低剂量摄入，也会对人类和动物健康产生重要的毒性影响。在大鼠中连续 23 天口服胡椒碱（1.12mg/kg），似乎可以干扰黄曲霉毒素的毒性，减少实验性中毒动物的肝损伤和白细胞耗竭。
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本文引用的文献
1
Cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study.
Eur J Pharmacol. 2007 Dec 8;576(1-3):160-70. doi: 10.1016/j.ejphar.2007.07.033. Epub 2007 Jul 25.
2
Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis.
Mol Cell Biochem. 2005 Jan;268(1-2):141-7. doi: 10.1007/s11010-005-3702-z.
3
Immunotoxicological effects of piperine in mice.
Toxicology. 2004 Mar 15;196(3):229-36. doi: 10.1016/j.tox.2003.10.006.
4
Inhibition of various functions in murine peritoneal macrophages by aflatoxin B1 exposure in vivo.
Int J Immunopharmacol. 1999 Jan;21(1):47-58. doi: 10.1016/s0192-0561(98)00069-1.
5
Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1.
J Ethnopharmacol. 1997 Nov;58(3):165-73. doi: 10.1016/s0378-8741(97)00104-9.
6
Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line.
Biochem Biophys Res Commun. 1996 Jan 17;218(2):562-9. doi: 10.1006/bbrc.1996.0100.
7
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
J Pharmacol Exp Ther. 1985 Jan;232(1):258-62.
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