IMDEA-Food Institute, Madrid, Spain.
Nutr Rev. 2013 Sep;71(9):585-99. doi: 10.1111/nure.12051. Epub 2013 Aug 1.
The population is aging. Over the coming years, the incidence of age-related chronic diseases such as cancer is expected to continue to increase. Phytochemicals, which are non-nutritive chemicals found in plants and food, have emerged as modulators of key cellular signaling pathways exerting proven anticancer effects. The challenge now is to develop personalized supplements comprised of specific phytochemicals for each clinical situation. This will be possible once a better understanding is gained of the molecular basis explaining the impact of phytochemicals on human health. The aim of the present literature review is to summarize current knowledge of the dietary phytochemicals with proven antitumor activity, with a special emphasis placed on their molecular targets. Also discussed are the limits of existing research strategies and the future directions of this field.
人口老龄化。在未来几年，预计与年龄相关的慢性疾病（如癌症）的发病率将继续上升。植物化学物质是存在于植物和食物中的非营养性化学物质，它们已成为调节关键细胞信号通路的调节剂，具有已证明的抗癌作用。现在的挑战是为每种临床情况开发由特定植物化学物质组成的个性化补充剂。一旦更好地了解植物化学物质对人类健康影响的分子基础，就有可能实现这一目标。本文献综述的目的是总结具有已证明抗肿瘤活性的膳食植物化学物质的最新知识，特别强调它们的分子靶标。还讨论了现有研究策略的局限性和该领域的未来方向。
