Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, India.
Post Graduate Department of Botany, Berhampur University, Berhampur, Odisha, India.
Phytother Res. 2021 Aug;35(8):4194-4214. doi: 10.1002/ptr.7082. Epub 2021 Mar 22.
The global incidence of cancer and cancer-related mortality is expected to rise in recent years despite advancements in cancer diagnosis and therapeutics. Increasing evidences of decrypting molecular mechanisms underlying cancer progression have commanded the tremendous development of synthetic anticancer drugs. With limitations in the current conventional cancer therapeutic approaches, the non-nutritive dietary phytochemicals have emerged as potent modulators of apoptosis and autophagy associated key signaling pathways in various cancer cells. The dynamic regulation of apoptosis and autophagy by phytochemicals in cancer are identified as promising therapeutic candidates with minimal cytotoxicity and enhanced biological activity. Dietary phytochemicals and their synthetic analogs have exhibited potency in the modulation of apoptosis and autophagy in several cancer cells as individuals or in combination with pre-existing FDA (Food and Drug Administration) approved anticancer drugs. In the current generation of medical science, developing precision and personalized medicine and their consumption as food supplements will hold high prevalence in cancer therapeutics. Hence understating the impact of dietary phytochemicals on human health and their molecular mechanism will thrive a new horizon in cancer therapeutics. Hence, this review has emphasized the role of apoptotic/autophagy modulating dietary phytochemicals in cancer therapy, their preclinical and clinical applications and the future direction of enhanced nano-formulation for better clinical efficacy.
尽管癌症诊断和治疗学取得了进展，但近年来全球癌症发病率和癌症相关死亡率预计仍将上升。越来越多的证据表明，癌症进展的分子机制被解密，这促使了合成抗癌药物的巨大发展。由于目前传统癌症治疗方法的局限性，非营养性膳食植物化学物质已成为各种癌细胞中凋亡和自噬相关关键信号通路的有效调节剂。植物化学物质在癌症中对凋亡和自噬的动态调节被确定为具有最小细胞毒性和增强生物活性的有前途的治疗候选物。膳食植物化学物质及其合成类似物在几种癌细胞中作为个体或与现有的 FDA（食品和药物管理局）批准的抗癌药物联合使用，在调节凋亡和自噬方面表现出效力。在当前一代医学科学中，开发精准和个性化药物并将其作为膳食补充剂使用将在癌症治疗中占据很高的地位。因此，了解膳食植物化学物质对人类健康的影响及其分子机制将为癌症治疗开辟新的前景。因此，本综述强调了凋亡/自噬调节膳食植物化学物质在癌症治疗中的作用、它们的临床前和临床应用以及增强纳米制剂以提高临床疗效的未来方向。
