关于RO-4-1284对小鼠拮抗作用的关键研究。
A critical study on RO-4-1284 antagonism in mice.
作者信息
Colpaert F C, Lenaerts F M, Niemegeers C J, Janssen P A
出版信息
Arch Int Pharmacodyn Ther. 1975 May;215(1):40-90.
PMID:240331
Abstract
Ro-4-1284 is found to produce ptosis, hypothermia, sedation and miosis in mice, and the antagonsim to these symptoms is investigated. The study reports the differential effects of various pharmacologically distinct classes of compounds. The relevance of this type of experiments to possible antidepressant drug activity is discussed.
摘要
发现Ro-4-1284可使小鼠出现上睑下垂、体温过低、镇静和瞳孔缩小，并对这些症状的拮抗作用进行了研究。该研究报告了各种药理学上不同类别的化合物的不同作用。讨论了这类实验与可能的抗抑郁药物活性的相关性。
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