Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Int J Dent Hyg. 2014 Feb;12(1):25-35. doi: 10.1111/idh.12050. Epub 2013 Aug 29.
Based on the existing scientific literature, the effect of chlorhexidine (CHX) dentifrice/gel as compared to a regular or placebo dentifrice/gel is established in healthy adults on the primary outcome parameters of plaque and gingivitis scores. As secondary parameter, tooth surface discoloration was evaluated as a side effect.
MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials were searched up to July 2013 to identify eligible studies. Included were (randomized) controlled clinical trials, regarding self-performed brushing by adults without periodontitis with a minimum duration of 4 weeks.
Independent screening of 389 unique titles and abstracts resulted in 16 comparisons. Of these, nine evaluated CHX dentifrice (0.4-1.0%) and 7 CHX gel (0.2-2.0%). It was not possible to perform a meta-analysis; therefore, a descriptive analysis was carried out. Regarding plaque score reduction, the majority of the experiments using a CHX dentifrice provided a significant positive effect. All studies assessing gingival bleeding as parameter for gingivitis observed a significant reduction in favour of CHX dentifrice over placebo dentifrice. Tooth surface discoloration was more pronounced with CHX dentifrice. The combined data concerning parameters of interest for CHX gel compared with a placebo did not show a trend towards a beneficial effect on plaque and bleeding scores.
Within the limitations of this analysis, it may be concluded that toothbrushing with a CHX gel does not provide conclusive evidence. Brushing with a CHX dentifrice can be effective with regard to the control of plaque and gingivitis. Tooth surface discoloration was observed as side effect, which potentially can have a negative impact on patients' compliance.
基于现有的科学文献，评估洗必泰（CHX）牙膏/凝胶与普通牙膏/凝胶相比，在健康成年人中对菌斑和牙龈炎评分的主要结局参数的效果。作为次要参数，评估牙面变色作为副作用。
检索 MEDLINE、EMBASE 和 Cochrane 对照试验中心注册库，截至 2013 年 7 月，以确定合格的研究。纳入（随机）对照临床试验，涉及无牙周炎的成年人自行刷牙，持续时间至少 4 周。
独立筛选 389 个独特的标题和摘要，得出 16 项比较。其中，9 项评估了 CHX 牙膏（0.4-1.0%），7 项评估了 CHX 凝胶（0.2-2.0%）。由于无法进行荟萃分析，因此进行了描述性分析。关于菌斑评分降低，大多数使用 CHX 牙膏的实验都提供了显著的积极效果。所有评估牙龈炎作为参数的研究都观察到 CHX 牙膏相对于安慰剂牙膏的牙龈出血显著减少。牙面变色在 CHX 牙膏中更为明显。关于 CHX 凝胶与安慰剂相比的参数的综合数据，并没有显示出对菌斑和出血评分有益的趋势。
在本分析的限制范围内，可以得出结论，用 CHX 凝胶刷牙不能提供确凿的证据。用 CHX 牙膏刷牙可以有效地控制菌斑和牙龈炎。牙面变色作为副作用观察到，这可能对患者的依从性产生负面影响。
