Holman B L, Tumeh S S
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115.
JAMA. 1990 Jan 26;263(4):561-4.
Single-photon emission computed tomography has received increasing attention as radiopharmaceuticals that reflect perfusion, metabolism, and receptor and cellular function have become widely available. Perfusion single-photon emission computed tomography of the brain provides functional information useful for the diagnosis and management of stroke, dementia, and epilepsy. Single-photon emission computed tomography has been applied to myocardial, skeletal, hepatic, and tumor scintigraphy, resulting in increased diagnostic accuracy over planar imaging because background activity and overlapping tissues interfere far less with activity from the target structure when tomographic techniques are used. Single-photon emission computed tomography is substantially less expensive and far more accessible than positron emission tomography and will become an increasingly attractive alternative for transferring the positron emission tomography technology to routine clinical use. In addition, single-photon emission computed tomography has unique applications that are increasingly finding their way into the routine practice of clinical nuclear medicine.
随着反映灌注、代谢、受体及细胞功能的放射性药物广泛可得，单光子发射计算机断层扫描（SPECT）受到了越来越多的关注。脑灌注单光子发射计算机断层扫描可为中风、痴呆和癫痫的诊断及治疗提供有用的功能信息。单光子发射计算机断层扫描已应用于心肌、骨骼、肝脏和肿瘤闪烁显像，与平面显像相比，其诊断准确性有所提高，因为使用断层扫描技术时，背景活性和重叠组织对靶结构活性的干扰要小得多。单光子发射计算机断层扫描比正电子发射断层扫描（PET）成本低得多，且更容易获得，将成为将正电子发射断层扫描技术转化为常规临床应用的越来越有吸引力的替代方法。此外，单光子发射计算机断层扫描有独特的应用，正越来越多地进入临床核医学的常规实践。
