OBJECTIVE: To illustrate the knowledge hotspots and cutting-edge research trends of F-FDG PET/CT radiomics, the knowledge structure of was systematically explored and the visualization map was analyzed. METHODS: Studies related to F-FDG PET/CT radiomics from 2013 to 2021 were identified and selected from the Web of Science Core Collection (WoSCC) using retrieval formula based on an interview. Bibliometric methods are mainly performed by CiteSpace 5.8.R3, which we use to build knowledge structures including publications, collaborative and co-cited studies, burst analysis, and so on. The performance and relevance of countries, institutions, authors, and journals were measured by knowledge maps. The research foci were analyzed through research of keywords, as well as literature co-citation analysis. Predicting trends of F-FDG PET/CT radiomics in this field utilizes a citation burst detection method. RESULTS: Through a systematic literature search, 457 articles, which were mainly published in the United States (120 articles) and China (83 articles), were finally included in this study for analysis. Memorial Sloan-Kettering Cancer Center and Southern Medical University are the most productive institutions, both with a frequency of 17. F-FDG PET/CT radiomics-related literature was frequently published with high citation in (IF9.236, 2020), (IF6.244, 2020), and (IF6.639, 2020). Further cluster profile of keywords and literature revealed that the research hotspots were primarily concentrated in the fields of image, textural feature, and positron emission tomography, and the hot research disease is a malignant tumor. Document co-citation analysis suggested that many scholars have a co-citation relationship in studies related to imaging biomarkers, texture analysis, and immunotherapy simultaneously. Burst detection suggests that adenocarcinoma studies are frontiers in F-FDG PET/CT radiomics, and the landmark literature put emphasis on the reproducibility of F-FDG PET/CT radiomics features. CONCLUSION: First, this bibliometric study provides a new perspective on F-FDG PET/CT radiomics research, especially for clinicians and researchers providing scientific quantitative analysis to measure the performance and correlation of countries, institutions, authors, and journals. Above all, there will be a continuing growth in the number of publications and citations in the field of F-FDG PET/CT. Second, the international research frontiers lie in applying F-FDG PET/CT radiomics to oncology research. Furthermore, new insights for researchers in future studies will be adenocarcinoma-related analyses. Moreover, our findings also offer suggestions for scholars to give attention to maintaining the reproducibility of F-FDG PET/CT radiomics features.