Bioinformatics Research Group, Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
Int J Mol Sci. 2013 Sep 12;14(9):18790-808. doi: 10.3390/ijms140918790.
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Moreover, lncRNAs are dysregulated in a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders, and various cancers, which indicates their important roles in these diseases. Here, we reviewed the current understanding of lncRNAs, including their definition and subclassification, regulatory functions, and potential roles in different types of complex human diseases.
长链非编码 RNA（lncRNAs）是一类异质性的 RNA，通常被定义为长度超过 200 个核苷酸的非蛋白编码转录本。最近，越来越多的研究表明，lncRNAs 可以参与多种关键的生物学过程，如染色质重塑、基因转录以及蛋白质的运输和转运。此外，lncRNAs 在许多复杂的人类疾病中失调，包括冠状动脉疾病、自身免疫性疾病、神经紊乱和各种癌症，这表明它们在这些疾病中发挥着重要作用。在这里，我们综述了 lncRNAs 的最新研究进展，包括它们的定义和分类、调控功能以及在不同类型复杂人类疾病中的潜在作用。
