Technical University of Denmark, Department of Electrical Engineering, Kgs. Lyngby, Denmark.
J Magn Reson. 2013 Nov;236:26-30. doi: 10.1016/j.jmr.2013.08.007. Epub 2013 Aug 23.
Hyperpolarization by the dissolution dynamic nuclear polarization (DNP) technique permits the generation of high spin polarization of solution state. However, sample formulation for dissolution-DNP is often difficult, as concentration and viscosity must be optimized to yield a dissolved sample with sufficient concentration, while maintaining polarization during the dissolution process. The unique chemical properties of choline permit the generation of highly soluble salts as well as deep eutectic mixtures with carboxylic acids and urea. We describe the formulation of these samples and compare their performance to more traditional sample formulations. Choline yields stable samples with exceptional polarization performance while simultaneously offering the capability to easily remove the choline after dissolution, perform experiments with the hyperpolarized choline, or anything in between.
通过溶解动态核极化（DNP）技术的极化作用，可以实现溶液状态下的高自旋极化。然而，溶解-DNP 的样品配方通常很困难，因为必须优化浓度和粘度，以产生具有足够浓度的溶解样品，同时在溶解过程中保持极化。胆碱的独特化学性质允许其与羧酸和尿素生成高溶解度的盐以及深共晶混合物。我们描述了这些样品的配方，并将其性能与更传统的样品配方进行了比较。胆碱可生成稳定的样品，具有出色的极化性能，同时还提供了易于在溶解后去除胆碱、用超极化胆碱进行实验或在两者之间进行任何操作的能力。
