Department of Pediatric Pulmonology and Pediatric Allergy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands,
Plant Foods Hum Nutr. 2013 Dec;68(4):391-5. doi: 10.1007/s11130-013-0385-6.
Patients with Oral Allergy Syndrome (OAS) to fresh apple may tolerate low allergenic apple cultivars. We aimed to investigate if the low allergenic properties of Elise and Santana, as previously identified in a Dutch population, could be generalised within North West Europe within the birch pollen region with regard to both the prevalence and degree of sensitization. Prick-to-prick tests (PTP) were performed in eighty-five adult patients with OAS to fresh apple in Great Britain, Switzerland and Northern Italy, before the birch pollen season, using the putatively low allergenic apple cultivars Elise, Santana, Granny Smith, Modi and Mcintosh, as well as the putatively high allergenic apple cultivars Golden Delicious and Kanzi. No significant differences in percentages of negative responses of PTPs were found between the three countries. Negative responses did not differ from negative responses to the different apple cultivars we previously found in 2006/2007 in the Netherlands. The size of the PTPs of all apple cultivars tested were correlated to the size of the skin prick tests with birch pollen. These results add to the indications for the low allergenic properties of the low allergenic apple cultivars Santana and Elise, as the number of negative responses were reproducible in three countries within the birch pollen region and were similar to previous results in the Netherlands. These results justify oral challenge studies with Elise and Santana within the birch pollen region, to establish the low allergenic properties for the benefit for apple allergic consumers for definite conclusions.
患有新鲜苹果口腔过敏症（OAS）的患者可能耐受低变应原性的苹果品种。我们旨在研究，如果先前在荷兰人群中鉴定出的 Elise 和 Santana 的低变应原特性是否可以在桦树花粉区域的西北欧范围内普遍存在，就新鲜苹果的患病率和致敏程度而言。在桦树花粉季节之前，在英国、瑞士和意大利北部的 85 名成年 OAS 患者中进行了点刺试验（PTP），使用疑似低变应原性的苹果品种 Elise、Santana、Granny Smith、Modi 和 McIntosh，以及疑似高变应原性的苹果品种 Golden Delicious 和 Kanzi。三个国家之间 PTP 的阴性反应百分比没有显著差异。阴性反应与我们之前在 2006/2007 年在荷兰发现的不同苹果品种的阴性反应没有差异。测试的所有苹果品种的 PTP 大小与桦树花粉的皮肤点刺试验大小相关。这些结果为低变应原性苹果品种 Santana 和 Elise 的低变应原特性提供了更多的证据，因为在桦树花粉区域的三个国家中，阴性反应的数量是可重复的，并且与荷兰的先前结果相似。这些结果证明了在桦树花粉区域进行 Elise 和 Santana 的口服挑战研究的合理性，以确定低变应原性特性，从而为苹果过敏消费者带来明确的结论。
