Fehérvari Zoltán, Sakaguchi Shimon
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
J Clin Invest. 2004 Nov;114(9):1209-17. doi: 10.1172/JCI23395.
Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.
近年来，调节性T细胞（Tregs）已成为免疫研究中的热门课题。大量实验数据现已证实，特别是自然产生的CD25 + CD4 + Tregs在维持自身耐受性方面发挥着关键作用，其功能障碍会导致严重甚至致命的免疫病理学。现在已知Tregs的影响范围远远超出免疫耐受的维持，并涉及从癌症到传染病等一系列临床上重要的领域。在人类和小鼠免疫系统中鉴定特定分子标志物，使得对这些细胞进行前所未有的研究成为可能，并且应该是最终释放其临床潜力的关键。
