Sarkar Dhruba, Melkonyan Ferdinand S, Gulevich Anton V, Gevorgyan Vladimir
Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor Street, Rm 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup.
Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10800-4. doi: 10.1002/anie.201304884. Epub 2013 Aug 22.
Two-fold unsymmetrical functionalization of arenes, which includes sequential halogenation/oxygenation reactions, has been developed. This transformation allows for a general and efficient synthesis of substituted -halophenols from simple aryl iodides. Importantly, the PyrDipSi (2-diisopropylsilylpyrimidine) group can be easily removed or efficiently converted into valuable functionalities.
芳烃的双不对称官能团化反应已被开发出来，该反应包括连续的卤化/氧化反应。这种转化能够从简单的芳基碘化物出发，实现取代卤代酚的通用且高效的合成。重要的是，PyrDipSi（2-二异丙基硅基嘧啶）基团可以很容易地被去除或高效地转化为有价值的官能团。
