葡萄糖饥饿对酵母烟酰胺腺嘌呤二核苷酸磷酸依赖性谷氨酸脱氢酶的影响。
Effect of glucose starvation on the nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase of yeast.
作者信息
Mazón M J
出版信息
J Bacteriol. 1978 Feb;133(2):780-5. doi: 10.1128/jb.133.2.780-785.1978.
Abstract
Yeast cells growing on mineral medium plus ammonia and glucose contained high levels of nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase activity, as measured in crude extracts. After suspension of cells in fresh medium lacking glucose, there was a loss of the glutamate dehydrogenase activity. Loss of activity was inhibited by 2,4-dinitrophenol, sodium azide, iodoacetic acid, and cycloheximide. The enzyme activity was restored when glucose was added back to the medium, and this recovery was fully prevented in the presence of cycloheximide.
摘要
在添加了氨和葡萄糖的矿物质培养基上生长的酵母细胞，其粗提取物中烟酰胺腺嘌呤二核苷酸磷酸依赖性谷氨酸脱氢酶活性水平很高。将细胞悬浮于缺乏葡萄糖的新鲜培养基中后，谷氨酸脱氢酶活性丧失。2,4-二硝基苯酚、叠氮化钠、碘乙酸和环己酰亚胺可抑制活性丧失。当向培养基中重新添加葡萄糖时，酶活性得以恢复，而在环己酰亚胺存在的情况下，这种恢复被完全阻止。
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