总状毛霉中与形态相关的烟酰胺腺嘌呤二核苷酸依赖性谷氨酸脱氢酶表达
Morphology-associated expression nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase in Mucorracemosus.
作者信息
Peters J, Sypherd P S
出版信息
J Bacteriol. 1979 Mar;137(3):1134-9. doi: 10.1128/jb.137.3.1134-1139.1979.
Abstract
The in vivo regulation of glutamate dehydrogenase (GDH) was studied in Mucor racemosus as a function of nutritional conditions and morphological state. Both nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP)-dependent GDH activities were found. The effect of carbon and nitrogen source on the specific activity of the NAD-dependent GDH suggests that its role is primarily catabolic. The NAD-dependent activity was generally an order of magnitude greater in mycelial cells than in yeast-phase cells grown on the same medium. During yeast-to-hyphal morphogenesis the increase in NAD-dependent activity preceded the appearance of hyphal cells both under aerobic and anaerobic conditions. Exogenous dibutyryl-cyclic AMP prevented the increase in NAD-dependent GDH concomitantly with the suppression of morphological differentiation. The NADP-dependent activity did not change appreciably during morphogenesis.
摘要
研究了总状毛霉中谷氨酸脱氢酶（GDH）的体内调节与营养条件和形态状态的关系。发现了烟酰胺腺嘌呤二核苷酸（NAD）和烟酰胺腺嘌呤二核苷酸磷酸（NADP）依赖性的GDH活性。碳源和氮源对NAD依赖性GDH比活性的影响表明其作用主要是分解代谢。在同一培养基上生长的菌丝体细胞中，NAD依赖性活性通常比酵母相细胞高一个数量级。在酵母到菌丝体形态发生过程中，无论有氧还是无氧条件下，NAD依赖性活性的增加都先于菌丝细胞的出现。外源性二丁酰环磷酸腺苷（dibutyryl-cyclic AMP）在抑制形态分化的同时，阻止了NAD依赖性GDH的增加。在形态发生过程中，NADP依赖性活性没有明显变化。
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