总状毛霉中与形态相关的烟酰胺腺嘌呤二核苷酸依赖性谷氨酸脱氢酶表达
Morphology-associated expression nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase in Mucorracemosus.
作者信息
Peters J, Sypherd P S
出版信息
J Bacteriol. 1979 Mar;137(3):1134-9. doi: 10.1128/jb.137.3.1134-1139.1979.
Abstract
The in vivo regulation of glutamate dehydrogenase (GDH) was studied in Mucor racemosus as a function of nutritional conditions and morphological state. Both nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP)-dependent GDH activities were found. The effect of carbon and nitrogen source on the specific activity of the NAD-dependent GDH suggests that its role is primarily catabolic. The NAD-dependent activity was generally an order of magnitude greater in mycelial cells than in yeast-phase cells grown on the same medium. During yeast-to-hyphal morphogenesis the increase in NAD-dependent activity preceded the appearance of hyphal cells both under aerobic and anaerobic conditions. Exogenous dibutyryl-cyclic AMP prevented the increase in NAD-dependent GDH concomitantly with the suppression of morphological differentiation. The NADP-dependent activity did not change appreciably during morphogenesis.
摘要
研究了总状毛霉中谷氨酸脱氢酶（GDH）的体内调节与营养条件和形态状态的关系。发现了烟酰胺腺嘌呤二核苷酸（NAD）和烟酰胺腺嘌呤二核苷酸磷酸（NADP）依赖性的GDH活性。碳源和氮源对NAD依赖性GDH比活性的影响表明其作用主要是分解代谢。在同一培养基上生长的菌丝体细胞中，NAD依赖性活性通常比酵母相细胞高一个数量级。在酵母到菌丝体形态发生过程中，无论有氧还是无氧条件下，NAD依赖性活性的增加都先于菌丝细胞的出现。外源性二丁酰环磷酸腺苷（dibutyryl-cyclic AMP）在抑制形态分化的同时，阻止了NAD依赖性GDH的增加。在形态发生过程中，NADP依赖性活性没有明显变化。
相似文献
1
Morphology-associated expression nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase in Mucorracemosus.总状毛霉中与形态相关的烟酰胺腺嘌呤二核苷酸依赖性谷氨酸脱氢酶表达
J Bacteriol. 1979 Mar;137(3):1134-9. doi: 10.1128/jb.137.3.1134-1139.1979.
2
Regulation of the nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenases of Saccharomyces cerevisiae.酿酒酵母中烟酰胺腺嘌呤二核苷酸和烟酰胺腺嘌呤二核苷酸磷酸依赖性谷氨酸脱氢酶的调控
J Bacteriol. 1973 Oct;116(1):367-72. doi: 10.1128/jb.116.1.367-372.1973.
3
Inorganic nitrogen assimilation in yeasts: alteration in enzyme activities associated with changes in cultural conditions and growth phase.酵母中的无机氮同化作用：与培养条件和生长阶段变化相关的酶活性改变。
J Bacteriol. 1972 Jan;109(1):25-33. doi: 10.1128/jb.109.1.25-33.1972.
4
Regulation of glutamate dehydrogenases during morphogenesis of Schizophyllum commune.裂褶菌形态发生过程中谷氨酸脱氢酶的调控
J Bacteriol. 1967 Mar;93(3):904-13. doi: 10.1128/jb.93.3.904-913.1967.
5
Cyclic adenosine 3',5'-monophosphate and morphogenesis in Mucor racemosus.环状3',5'-单磷酸腺苷与总状毛霉的形态发生
J Bacteriol. 1974 Feb;117(2):432-8. doi: 10.1128/jb.117.2.432-438.1974.
6
Significance of NADP/NAD glutamate dehydrogenase ratio in the dimorphic behavior of Benjaminiella poitrasii and its morphological mutants.NADP/NAD谷氨酸脱氢酶比率在波氏拟本杰明酵母及其形态突变体双态行为中的意义
J Bacteriol. 1992 Jun;174(11):3723-8. doi: 10.1128/jb.174.11.3723-3728.1992.
7
Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis.谷氨酸脱氢酶和谷氨酰胺合成酶可响应氮可用性在耻垢分枝杆菌中进行调节。
BMC Microbiol. 2010 May 11;10:138. doi: 10.1186/1471-2180-10-138.
8
Multiple regulatory processes in nicotinamide adenine dinucleotide-specific glutamic dehydrogenases. Catabolite repression; nicotinamide adenine dinucleotide phosphate, reduced nicotinamide adenine dinucleotide phosphate, and phosphoenolpyruvate as activators; allosteric inhibition by substrates.烟酰胺腺嘌呤二核苷酸特异性谷氨酸脱氢酶中的多种调控过程。分解代谢物阻遏；烟酰胺腺嘌呤二核苷酸磷酸、还原型烟酰胺腺嘌呤二核苷酸磷酸和磷酸烯醇丙酮酸作为激活剂；底物的别构抑制。
J Biol Chem. 1970 Aug 10;245(15):3890-900.
9
Possible involvement of cyclic adenosine 3',5'-monophosphate in the regulation of NADP-/NAD-glutamate dehydrogenase ratio and in yeast-mycelium transition of Benjaminiella poitrasii.环磷酸腺苷可能参与调节波氏拟小克银汉霉中NADP⁺/NAD⁺-谷氨酸脱氢酶的比例以及酵母-菌丝体转变过程。
J Bacteriol. 1993 Sep;175(18):6052-5. doi: 10.1128/jb.175.18.6052-6055.1993.
10
Evidence for two species of glutamate dehydrogenases in Thiobacillus novellus.新型硫杆菌中两种谷氨酸脱氢酶的证据。
J Bacteriol. 1968 Jan;95(1):87-94. doi: 10.1128/jb.95.1.87-94.1968.
引用本文的文献
1
A metabolomic study of the effect of glutamate dehydrogenase deletion on growth and morphogenesis.谷氨酸脱氢酶缺失对生长和形态发生影响的代谢组学研究。
NPJ Biofilms Microbiomes. 2019 Apr 8;5(1):13. doi: 10.1038/s41522-019-0086-5. eCollection 2019.
2
Inhibitors of amino acids biosynthesis as antifungal agents.作为抗真菌剂的氨基酸生物合成抑制剂。
Amino Acids. 2015 Feb;47(2):227-49. doi: 10.1007/s00726-014-1873-1. Epub 2014 Nov 20.
3
Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics.通过定量蛋白质组学揭示钙调神经磷酸酶与 COPI 蛋白 Sec28 和 COPII 蛋白 Sec13 的关联。
PLoS One. 2011;6(10):e25280. doi: 10.1371/journal.pone.0025280. Epub 2011 Oct 3.
4
Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae.转录组分析揭示了对稻瘟病菌稻瘟菌附着胞形成和功能的新见解。
Genome Biol. 2008;9(5):R85. doi: 10.1186/gb-2008-9-5-r85. Epub 2008 May 20.
5
Possible involvement of cyclic adenosine 3',5'-monophosphate in the regulation of NADP-/NAD-glutamate dehydrogenase ratio and in yeast-mycelium transition of Benjaminiella poitrasii.环磷酸腺苷可能参与调节波氏拟小克银汉霉中NADP⁺/NAD⁺-谷氨酸脱氢酶的比例以及酵母-菌丝体转变过程。
J Bacteriol. 1993 Sep;175(18):6052-5. doi: 10.1128/jb.175.18.6052-6055.1993.
6
Glyoxylate cycle in Mucor racemosus.总状毛霉中的乙醛酸循环。
J Bacteriol. 1980 Jul;143(1):416-21. doi: 10.1128/jb.143.1.416-421.1980.
7
Effect of hexoses on the levels of pyruvate decarboxylase in Mucor rouxii.己糖对鲁氏毛霉中丙酮酸脱羧酶水平的影响。
J Bacteriol. 1980 Jun;142(3):1029-31. doi: 10.1128/jb.142.3.1029-1031.1980.
8
Adenosine 3',5'-phosphate in fungi.真菌中的3',5'-磷酸腺苷
Microbiol Rev. 1981 Sep;45(3):462-80. doi: 10.1128/mr.45.3.462-480.1981.
9
Relationship of internal cyclic AMP levels, rates of protein synthesis and mucor dimorphism.细胞内环磷酸腺苷水平、蛋白质合成速率与毛霉双态性的关系。
Arch Microbiol. 1981 Jul;129(5):353-6. doi: 10.1007/BF00406461.
10
Purification of a soluble and a wall-bound form of beta-glucosidase from Mucor racemosus.从总状毛霉中纯化一种可溶性和一种细胞壁结合形式的β-葡萄糖苷酶。
J Bacteriol. 1982 Feb;149(2):515-22. doi: 10.1128/jb.149.2.515-522.1982.
本文引用的文献
1
Effect of glutamic acid on the formation of two glutamic acid dehydrogenases of Neurospora.谷氨酸对粗糙脉孢菌两种谷氨酸脱氢酶形成的影响。
Biochem Biophys Res Commun. 1962 Jan 24;6:404-9. doi: 10.1016/0006-291x(62)90364-9.
2
Catabolite repression.分解代谢物阻遏
Cold Spring Harb Symp Quant Biol. 1961;26:249-56. doi: 10.1101/sqb.1961.026.01.031.
3
Nutrition, growth, and morphogenesis of Mucor rouxii.鲁氏毛霉的营养、生长与形态发生
J Bacteriol. 1962 Oct;84(4):841-58. doi: 10.1128/jb.84.4.841-858.1962.
4
Induction of yeast-like development in Mucor by carbon dioxide.二氧化碳诱导毛霉产生酵母样发育。
J Bacteriol. 1962 Oct;84(4):829-40. doi: 10.1128/jb.84.4.829-840.1962.
5
Glutamic dehydrogenase in single-gene mutants of Neurospora deficient in amination.在氨基化缺陷的粗糙脉孢菌单基因突变体中的谷氨酸脱氢酶
Nature. 1961 Apr 15;190:286-7. doi: 10.1038/190286a0.
6
Nutritional requirements for growth and yeastlike development of Mucor rouxii under carbon dioxide.鲁氏毛霉在二氧化碳条件下生长及酵母样发育的营养需求
J Bacteriol. 1970 Feb;101(2):595-602. doi: 10.1128/jb.101.2.595-602.1970.
7
Inorganic nitrogen assimilation in yeasts: alteration in enzyme activities associated with changes in cultural conditions and growth phase.酵母中的无机氮同化作用：与培养条件和生长阶段变化相关的酶活性改变。
J Bacteriol. 1972 Jan;109(1):25-33. doi: 10.1128/jb.109.1.25-33.1972.
8
Glutamic dehydrogenases of Oomycetes. Kinetic mechanism and possible vvolutionary history.卵菌纲的谷氨酸脱氢酶。动力学机制及可能的进化史。
J Biol Chem. 1971 Apr 10;246(7):2127-35.
9
Effect of glucose, galactose, and different nitrogen-sources on the activity of yeast glutamate dehydrogenase (NAD and NADP-linked) from normal strain and impaired respiration mutant.葡萄糖、半乳糖和不同氮源对正常菌株和呼吸受损突变体的酵母谷氨酸脱氢酶（NAD和NADP连接型）活性的影响。
Eur J Biochem. 1970 Nov;16(3):567-70. doi: 10.1111/j.1432-1033.1970.tb01118.x.
10
Catabolite-controlled regulation of glutamate dehydrogenases of Neurospora crassa.粗糙脉孢菌谷氨酸脱氢酶的分解代谢物控制调节
Can J Microbiol. 1970 Jan;16(1):33-40. doi: 10.1139/m70-006.
Zotero 插件