Li Min, Chen Yingmin, Luo Zhangyuan, Zhang Wenzan, He Ben
Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai, China.
Int J Clin Exp Med. 2013 Sep 1;6(8):614-20. eCollection 2013.
Bipolar ablation is an innovative direction of catheter ablation technology. The aim of this study was to investigate the damaged area of bipolar radiofrequency ablation in vitro pigs' hearts under different conditions and to evaluate the effectiveness and safety. The bipolar radiofrequency ablation was performed in vitro pigs' hearts with a 4 mm bipolar electrode under different conditions at various combinations of the parameters (Distance: from 12 mm to 17 mm; Power: 30 w or 40 w; Time: from 20 s to 90 s; Temperature: 45°C or 60°C; Saline Perfusion: 0 ml/h, 1000 ml/h or 1500 ml/h). We measured the length, width, depth, connection rate and blasting rate of the connective ablation lesion and then evaluated the effectiveness and safety of connective ablation lesion. Numerical analysis showed that there was a positive correlation between the time, temperature and the length, depth, connection rate, blasting rate. There was a negative correlation between the power, perfusion and the depth, while other indexes were positively correlated with the power, perfusion. Distance and length were positively correlated, while other indexes were negatively correlated with the distance. Regression analysis showed that the infusion was not significantly correlated with the depth, connection rate, blasting rate. The temperature was not significantly correlated with the length, connection rate. Power and depth's correlation was not significant. When the parameter combination was 12 mm, 20 s, 30 w, 60°C, 1500 ml/h, the effectiveness and safety was optimum, with the mean lesion length being 19.89 ± 3.02 mm, the depth of an average being 3.50 ± 0.63 mm, the connection rate and the blasting rate being 100% and 13.9% respectively. The bipolar ablation in vitro pigs' hearts could form the most stable continuous damage.
双极消融是导管消融技术的一个创新方向。本研究的目的是在不同条件下，研究双极射频消融在体外猪心脏中的损伤区域，并评估其有效性和安全性。使用4毫米双极电极在体外猪心脏上，于不同条件下以各种参数组合进行双极射频消融（距离：12毫米至17毫米；功率：30瓦或40瓦；时间：20秒至90秒；温度：45°C或60°C；盐水灌注：0毫升/小时、1000毫升/小时或1500毫升/小时）。我们测量了结缔组织消融灶的长度、宽度、深度、连接率和爆破率，然后评估结缔组织消融灶的有效性和安全性。数值分析表明，时间、温度与长度、深度、连接率、爆破率之间呈正相关。功率、灌注与深度之间呈负相关，而其他指标与功率、灌注呈正相关。距离与长度呈正相关，而其他指标与距离呈负相关。回归分析表明，灌注与深度、连接率、爆破率之间无显著相关性。温度与长度、连接率之间无显著相关性。功率与深度之间的相关性不显著。当参数组合为12毫米、20秒、30瓦、60°C、1500毫升/小时时，有效性和安全性最佳，平均损伤灶长度为19.89±3.02毫米，平均深度为3.50±0.63毫米，连接率和爆破率分别为100%和13.9%。体外猪心脏双极消融可形成最稳定的连续性损伤。
