高血压患者中促红细胞生成素的循环水平及其与动脉僵硬度的关系。

Circulating levels of erythropoietin and its relation to arterial stiffness in patients with hypertension.

作者信息

Gedikli Omer, Kiris Abdulkadir, Karahan Caner

机构信息

Department of Cardiology, Faculty of Medicine, Karadeniz Technical University Trabzon, Turkey.

出版信息

Int J Clin Exp Med. 2013 Sep 1;6(8):706-11. eCollection 2013.

PMID:24040481

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3762628/

Abstract

BACKGROUND

Emerging experimental and clinical data indicates that erythropoietin (EPO) have significant roles in the cardiovascular system. But the relationship between endogenous EPO levels and arterial stiffness remains unknown. We investigated the EPO levels in relation to arterial stiffness parameters in patients with never treated newly diagnosed hypertension (HT).

METHODS

We studied 42 (47.8 ± 10 years) never treated HT patients and age and gender-matched 40 (47 ± 8.6 years) normotensive individuals. Serum EPO levels were determined in all subjects using the chemiluminescence immunoassay kit. We evaluated heart rate-corrected augmentation index (AIx@75), a marker of wave reflections and aortic pulse wave velocity (PWV) as indices of elastic-type aortic stiffness using applanation tonometry (Sphygmocor).

RESULTS

The levels of EPO were not significantly different in hypertensive patients and the controls (10.6 ± 5 vs. 11.6 ± 9, mIU/mL, p = 0.5). Aortic PWV (10.3 ± 2.3 vs. 8.7 ± 1.6 m/s, p = 0.0001) and AIx@75 (22.7 ± 10 vs. 15 ± 11, %, p = 0.002) were significantly higher in hypertensive patients than the controls. EPO levels were not correlated with brachial and central pressures. Also EPO level was not significantly correlated with AIx@75 (r = -0.15, p = 0.17) and aortic PWV (r = -0.16, p = 0.13).

CONCLUSION

Results from this study indicate that endogenous EPO levels may not be a factor in development of increased arterial stiffness.

摘要

背景

新出现的实验和临床数据表明，促红细胞生成素（EPO）在心血管系统中具有重要作用。但内源性EPO水平与动脉僵硬度之间的关系尚不清楚。我们研究了初诊未治疗的高血压（HT）患者中EPO水平与动脉僵硬度参数的关系。

方法

我们研究了42名（47.8±10岁）初诊未治疗的HT患者以及40名（47±8.6岁）年龄和性别匹配的血压正常个体。使用化学发光免疫分析试剂盒测定所有受试者的血清EPO水平。我们使用压平式眼压计（Sphygmocor）评估心率校正的增强指数（AIx@75）（作为波反射的标志物）和主动脉脉搏波速度（PWV）作为弹性型主动脉僵硬度的指标。

结果

高血压患者和对照组的EPO水平无显著差异（10.6±5对11.6±9，mIU/mL，p = 0.5）。高血压患者的主动脉PWV（10.3±2.3对8.7±1.6 m/s，p = 0.0001）和AIx@75（22.7±10对15±11，%，p = 0.002）显著高于对照组。EPO水平与肱动脉压和中心动脉压均无相关性。此外，EPO水平与AIx@75（r = -0.15，p = 0.17）和主动脉PWV（r = -0.16，p = 0.13）也无显著相关性。