McMeeking A, Borkowsky W, Klesius P H, Bonk S, Holzman R S, Lawrence H S
Department of Medicine, New York University Medical Center, NY 10016.
J Infect Dis. 1990 Jan;161(1):108-12. doi: 10.1093/infdis/161.1.108.
Cryptosporidial infection causes severe diarrheal disease in patients with AIDS. Fourteen patients with AIDS and symptomatic cryptosporidiosis were treated with a specific bovine dialyzable leukocyte extract (immune DLE) prepared from lymph node lymphocytes of calves immunized with cryptosporidia or a nonspecific (nonimmune) DLE prepared from nonimmunized calves. Six of 7 patients given immune DLE gained weight and had a decrease in bowel movement frequency, with eradication of oocysts from stool in 5 patients. Six of 7 patients given nonimmune DLE showed no decrease in bowel movement and 4, no clearing of oocytes from stool; 5 continued to lose weight. Subsequently, 5 of these 7 were treated with immune DLE; 4 had a decrease in bowel movement frequency and significant weight gain, with eradication of oocytes from stool in 2 patients. Immune DLE produces sustained symptomatic improvement in patients with AIDS and active cryptosporidiosis, but lack of an appropriate cryptosporidial antigen allows only postulation that an augmentation of cellular immunity to Cryptosporidium parvum induced by immune DLE resulted in the microbiologic and clinical improvement observed.
隐孢子虫感染会在艾滋病患者中引发严重的腹泻疾病。14名患有艾滋病且有症状性隐孢子虫病的患者接受了一种特定的牛可透析白细胞提取物（免疫DLE）治疗，该提取物由用隐孢子虫免疫的小牛的淋巴结淋巴细胞制备而成，或接受了由未免疫小牛制备的非特异性（非免疫）DLE治疗。接受免疫DLE治疗的7名患者中有6人体重增加，排便频率降低，5名患者粪便中的卵囊被清除。接受非免疫DLE治疗的7名患者中有6名排便频率未降低，4名患者粪便中的卵母细胞未清除；5名患者持续体重减轻。随后，这7名患者中的5名接受了免疫DLE治疗；4名患者排便频率降低且体重显著增加，2名患者粪便中的卵母细胞被清除。免疫DLE可使患有艾滋病和活动性隐孢子虫病的患者症状持续改善，但由于缺乏合适的隐孢子虫抗原，只能推测免疫DLE诱导的针对微小隐孢子虫的细胞免疫增强导致了所观察到的微生物学和临床改善。
